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Visit our database :. Integrative Structural and Chemical Biology. 33 (0)4.86.97.73.31. INSERM) - Xavier Morelli. Which is further underscored by an expected reduced occurrence of resistance that might arise due to mutations in the protein-protein interface. In this context, our objectives are to identify, to understand, to validate and to target protein-protein interaction interfaces. INSERM) - Xavier Morelli. Laboratory of integrative Structural and Chemical Biology. Cancer Research Center of Marseille.

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iSCB home page | iscb.cnrs-mrs.fr Reviews

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Visit our database :. Integrative Structural and Chemical Biology. 33 (0)4.86.97.73.31. INSERM) - Xavier Morelli. Which is further underscored by an expected reduced occurrence of resistance that might arise due to mutations in the protein-protein interface. In this context, our objectives are to identify, to understand, to validate and to target protein-protein interaction interfaces. INSERM) - Xavier Morelli. Laboratory of integrative Structural and Chemical Biology. Cancer Research Center of Marseille.

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2 crcm

3 ipc

4 cancer

5 chemistry

6 marseille

7 drug-design

8 protein protein interaction

9 chemoproteomics

10 epigenetics

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iSCB home page | iscb.cnrs-mrs.fr Reviews

https://iscb.cnrs-mrs.fr

Visit our database :. Integrative Structural and Chemical Biology. 33 (0)4.86.97.73.31. INSERM) - Xavier Morelli. Which is further underscored by an expected reduced occurrence of resistance that might arise due to mutations in the protein-protein interface. In this context, our objectives are to identify, to understand, to validate and to target protein-protein interaction interfaces. INSERM) - Xavier Morelli. Laboratory of integrative Structural and Chemical Biology. Cancer Research Center of Marseille.

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iSCB publications

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Visit our database :. Betzi, S., Restouin, A., Arold, S.T., Parrot, I., Guerlesquin, F., Morelli, X*. and Collette, Y*. 2007) Protein-Protein Interaction Inhibition (2P2I) combining High Throughput and Virtual Screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci. Ohara, K., Smietana, M.*, Restouin, A., Mollard, S., Borg, J.P., Collette Y*. and Vasseur, J.-J. 2007) Amine-Guanidine Switch: A Promising Approach to Improve DNA Binding and Antiproliferative Activities, J. Med. Chem. Shi, X....

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iSCB people page

http://iscb.cnrs-mrs.fr/people.html

Visit our database :. Here is a picture taken in May 2015. For a lab restaurant lunch. From left to right:. Etienne Rebuffet, Xavier Morelli, Yves Collette, Hélène Launay, Brigitt Raux, Elsa Drivet, Stéphane Betzi, Sébastien Combes, Iuliia Voitovich, Laurent Hoffer, Véronique Brechot, Karine Barral, Sabine Milhas, Philippe Roche, Carine Derviaux, Marie-Jeanne Basse, Mathias Vanhems. Not in the picture:. Jean-Michel Brunel, Fatiha Benmansour. January 2011 (ID3 group).

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iSCB Platforms

http://iscb.cnrs-mrs.fr/platforms.html

Visit our database :. 33 (0)4.86.97.73.31. 33 (0)4.91.16.45.06. Has been created at the beginning of 2008 by Dr. Xavier Morelli. And Dr. Philippe Roche. To answer to an increasing demand of the academic laboratories regarding molecular modeling. Virtual mutagenesis mainly) and virtual screening. Hit finding and hit to lead optimization). The INT-3D platform is dedicated to the Acceleration of the discovery of new bioactive molecules. The know-how of this platform concerns mainly:. TrGET affers a variety ...

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iSCB home page

http://iscb.cnrs-mrs.fr/index.html

Visit our database :. Integrative Structural and Chemical Biology. 33 (0)4.86.97.73.31. INSERM) - Xavier Morelli. Which is further underscored by an expected reduced occurrence of resistance that might arise due to mutations in the protein-protein interface. In this context, our objectives are to identify, to understand, to validate and to target protein-protein interaction interfaces. INSERM) - Xavier Morelli. Laboratory of integrative Structural and Chemical Biology. Cancer Research Center of Marseille.

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2p2idb_archive.cnrs-mrs.fr

2P2I DB Overview (archive)

http://2p2idb_archive.cnrs-mrs.fr/index.html

Overview v1.0 (archive). In the very recent years the number of small molecule disrupting protein-protein interactions (PPIs). Has grown rapidly partly due to the improvement of in silico drug discovery methods. PPIs are now considered as the next generation of very promising therapeutic targets ( Roche and Morelli, 2010. Although a lot of PPI inhibitors have been discovered, little is known. About structural parameters that govern the druggability of protein-protein interactions. Have been analyzed in t...

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iscb.cnrs-mrs.fr

iSCB home page

Visit our database :. Integrative Structural and Chemical Biology. 33 (0)4.86.97.73.31. INSERM) - Xavier Morelli. Which is further underscored by an expected reduced occurrence of resistance that might arise due to mutations in the protein-protein interface. In this context, our objectives are to identify, to understand, to validate and to target protein-protein interaction interfaces. INSERM) - Xavier Morelli. Laboratory of integrative Structural and Chemical Biology. Cancer Research Center of Marseille.

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About ISCB - ISCB | International Society for Clinical Biostatistics

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