Projects - Stamm's Lab
A pre-mRNA is schematically shown. The transcriptional start site is shown as an arrow. Exons are shown as boxes, introns as lines. The consensus sequences for the branch point, 3’ splice site and 5’ splice site are indicated. See the full paper here. Project I: Molecular function of small RNAs derived from snoRNAs. We determine the molecular mechanisms that link the loss of SNORD115 and SNORD116 to the syndrome and obesity. Loss of SNORD115 could explain hyperphagia observed in PWS patients, since S...
Stamm's Lab - Overview
This process is known as pre-mRNA splicing. Often, a cell can alternatively include or exclude a sequence from the mature mRNA, a process that is known as alternative splicing. Read our latest review " Function of alternative splicing. We are studying how alternative splicing is regulated, especially through non-coding RNAs. Look at our latest review " Processing of snoRNAs as a new source of regulatory non-coding RNAs. And understand the cause for Prader-Willi syndrome, the most com.