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ActivX Site Probes - Welcome

ActivX has pioneered the development of active site probes to facilitate drug discovery and development efforts for targets in a variety of enzyme families including kinases, serine hydrolases, GTPases, and cathepsins. ActivX Biosciences, Inc.

http://www.activxprobes.com/

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CONTACTS AT ACTIVXPROBES.COM

ActivX Biosciences, Inc.

Helge Weissig

11025 N.●●●●●●●●ines Rd.

La ●●●lla , CA, 92037

United States

1.85●●●●2542
he●●●●@activx.com

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ActivX Biosciences, Inc.

Helge Weissig

11025 N.●●●●●●●●ines Rd.

La ●●●lla , CA, 92037

United States

1.85●●●●2542
he●●●●@activx.com

View this contact

ActivX Biosciences, Inc.

Helge Weissig

11025 N.●●●●●●●●ines Rd.

La ●●●lla , CA, 92037

United States

1.85●●●●2542
he●●●●@activx.com

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ActivX Site Probes - Welcome | activxprobes.com Reviews
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ActivX has pioneered the development of active site probes to facilitate drug discovery and development efforts for targets in a variety of enzyme families including kinases, serine hydrolases, GTPases, and cathepsins. ActivX Biosciences, Inc.
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KEYWORDS
1 technology
2 platforms
3 probes
4 kinases
5 other atpases
6 serine hydrolases
7 gtpases
8 cathepsins
9 others
10 news and publications
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ActivX Site Probes - Welcome | activxprobes.com Reviews

https://activxprobes.com

ActivX has pioneered the development of active site probes to facilitate drug discovery and development efforts for targets in a variety of enzyme families including kinases, serine hydrolases, GTPases, and cathepsins. ActivX Biosciences, Inc.

INTERNAL PAGES

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1

ActivX Site Probes - Caspase Probes

http://www.activxprobes.com/probes/gtp.html

Download GTPase Application Note. GTPases comprise a diverse family of enzymes that participate in a variety of cellular processes including signal transduction, protein synthesis, and intracellular transport. GTPases typically participate in these processes as binary switches; activating a process in the GTP-bound state and inactivating a process in the GDP bound state. Importantly, the deregulation of the GTP/GDP cycle for a number of GTPases are known to be associated with cancers.

2

ActivX Site Probes - Cathepsin Probes

http://www.activxprobes.com/probes/cathepsin.html

ActivX has developed cathepsin probes based on the acyloxymethyl ketone motif containing either fluorescent or desthiobiotin tags. The probes are cell-permeable and can be used to profile cathepsins or cathepsin inhibitors in either lysates or live cells. Profiling cathepsins in various proteomes by XSite™ (LC-MS. Profiling a cathepsin inhibitor in live cells. Profiling a cathepsin inhibitor in live HepG2 cells with the flourescent cathepsin probe by Xhibit™ (SDS-PAGE):. ActivX Biosciences, Inc.

3

ActivX Site Probes - Welcome

http://www.activxprobes.com/index.html

ActivX has pioneered the development of active site probes to facilitate drug discovery and development efforts for targets in a variety of enzyme families including kinases, serine hydrolases, GTPases, and cathepsins. ActivX Biosciences, Inc.

4

ActivX Site Probes - News

http://www.activxprobes.com/news.html

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry. Functional Interrogation of the Kinome Using Nucleotide Acyl Phosphates. Nomanbhoy TK, Rosenblum J, Aban A, Burbaum JJ. Inhibitor focusing: direct. Selection of drug targets from proteomes using activity-based probes. Assay Drug. Dev Technol. 2003 Feb;1(1 Pt 2):137-46. PubMed PMID: 15090140. Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET,. 28 PubMed PMID: 15795380; PubMed Central PMCID: PMC555687.

5

ActivX - Working With Us

http://www.activxprobes.com/business.html

Flexible Solutions, Powerful Results. Screening projects can be performed against native targets in any cell line or tissue from any species. Custom projects in any cell line or tissue, from any species. Comprehensive coverage of target families in your system of interest. Directly measure on- and off-target potency in your cellular or animal model. Profiling of treated cells or animal tissues. Seamless transition from lysate binding studies to live animal or cell treatments. ActivX Biosciences, Inc.

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ActivX - News and Publications

http://www.activx.com/about/news.html

John W. Kozarich Receives Director of the Year Awards 2014. ASSAY and Drug Development Technologies Interview with John W. Kozarich - by Vicki Glaser. Thermo Fisher Scientific Licenses Novel Activity-Based Protein Profiling Technology from ActivX Biosciences. ActivX Biosciences Head Receives Distinguished Scientist Award. ActivX Biosciences, Inc. Announces Positive Phase Ib and IIa Clinical Trial Results for KRP-104, a Flexible Dosing DPP-4 Inhibitor for Type 2 Diabetes. ActivX Biosciences, Inc.

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ActivX - About Us

http://www.activx.com/about/index.html

ActivX Biosciences, Inc.

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ActivX - Management

http://www.activx.com/about/management.html

John Kozarich, Ph.D, Chairman, President. Vice President, Chief Financial Officer. Lorrie Daggett, Vice President, Corporate Planning and Operations. Tyzoon Nomanbhoy, Ph.D., Director of Technology. Jonathan Rosenblum, Ph.D., Senior Director of Research. Helge Weissig, Ph.D., Director of Bioinformatics. ActivX Biosciences, Inc. A wholly owned subsidiary of Kyorin Pharmacuetical Co., Ltd.

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ActivX - Welcome

http://www.activx.com/index.html

ActivX Biosciences, Inc. A wholly owned subsidiary of Kyorin Pharmacuetical Co., Ltd.

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ActivX - Therapeutic Focus

http://www.activx.com/therapeutic-focus.html

Our current Therapeutic Focus at ActivX is in Oncology. The company has utilized its proprietary discovery platform to successfully develop a portfolio of competitively differentiated clinical and preclinical state programs in both metabolic disease and oncology. ActivX's most advanced drug, KRP-104, is currently in late-stage clinical trials for the treatment of diabetes. For more information about ActivX Targeted Probes or profiling needs please contact us. ActivX Biosciences, Inc.

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ActivX - Board of Directors

http://www.activx.com/about/scientific-advisory-board.html

Paul R. Schimmel, Ph.D., Chairman, SAB. Chairman, Professor, Department of Molecular Biology and The Skaggs Institute for Chemical Biology. Benjamin Cravatt, Ph.D., (co-founder of ActivX). Professor at the Skaggs Institute for Chemical Biology at The Scripps Research Institute. Hugh Rosen, M.D., Ph.D. Professor of Immunology, and Chairman of the Committee for Advanced Human Therapeutics at The Scripps Research Institute. Dale R. Boger, Ph.D. David L. Pompliano, Ph.D. ActivX Biosciences, Inc.

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ActivX - Careers

http://www.activx.com/careers.html

ActivX Biosciences, Inc. Is an emerging biopharmaceutical company that discovers and develops small molecule drugs for major unmet medical needs. ActivX uses its unique technology to discover novel disease mechanisms and to optimize drugs that impact these diseases. There are currently no openings. For more information about ActivX Targeted Probes or profiling needs please contact us. ActivX Biosciences, Inc. Probes available from Thermo Scientific. ActivX Biosciences, Inc.

activx.com activx.com

ActivX - Board of Directors

http://www.activx.com/about/board-of-directors.html

John Kozarich, Ph.D. Mr Yoh Ito, Vice President and Chief Financial Officer of ActivX, is also the Director of Finance and Accounting of Kyorin Pharmaceutical Co. Ltd. He joined Kyorin in 2003 and previously held the position of Senior Manager of Strategies and Business Development Headquarters. Prior to Kyorin, Mr. Ito was Managing Director of Capital Arts, Inc. He received his MBA from Cornell University and graduated from the University of Tokyo. Masakatsu Komuro, Ph.D. Koichiro Hagihara, Ph.D.

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ActivX - Welcome

ActivX Biosciences, Inc. A wholly owned subsidiary of Kyorin Pharmacuetical Co., Ltd.

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ActivX Site Probes - Welcome

ActivX has pioneered the development of active site probes to facilitate drug discovery and development efforts for targets in a variety of enzyme families including kinases, serine hydrolases, GTPases, and cathepsins. ActivX Biosciences, Inc.

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