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Ascomycin Macrolactams fact sheet

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

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Ascomycin Macrolactams fact sheet | ascomycin.4mg.com Reviews

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Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

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Ascomycin Macrolactams fact sheet | ascomycin.4mg.com Reviews

https://ascomycin.4mg.com

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

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ascomycin.4mg.com

1

Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative

http://ascomycin.4mg.com/a3.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Bioorg Med Chem Lett 1998 Apr 21;8(8):935-8. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative. Kawai M, Gunawardana IW, Mollison KW, Hsieh GC, Lane BC, Luly JR. Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.

2

The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils

http://ascomycin.4mg.com/a0.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. J Allergy Clin Immunol 2001 Aug;108(2):275-80. The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils. Zuberbier T, Chong SU, Grunow K, Guhl S, Welker P, Grassberger M, Henz BM. Department of Dermatology and Allergy, Charite, Humboldt University Berlin, Germany.

3

Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis

http://ascomycin.4mg.com/a5.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Arch Dermatol 1998 Jul;134(7):805-9. Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. Van Leent EJ, Graber M, Thurston M, Wagenaar A, Spuls PI, Bos JD. Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.

4

Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner

http://ascomycin.4mg.com/a4.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Arch Dermatol Res 1998 Sep;290(9):501-7. Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. Hultsch T, Muller KD, Meingassner JG, Grassberger M, Schopf RE, Knop J. University Hautklinik Mainz, Germany.

5

Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases

http://ascomycin.4mg.com/a1.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Curr Pharm Des 1998 Oct;4(5):367-79. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases. Abbott Laboratories, Abbott Park, Illinois, USA. karl.mollison@abbott.com.

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actinomycin.4mg.com

Actinomycin D

http://actinomycin.4mg.com/ab5.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Binding of Actinomycin D to Single-Stranded DNA of Sequence Motifs d(TGTCT(n)G) and d(TGT(n)GTCT). Biophys J 2003 Jan;84(1):432-9. Chen FM, Sha F, Chin KH, Chou SH. Department of Chemistry, Tennessee State University, Nashville, Tennessee 37209 USA and Institute of Biochemistry, National Chung Hsing University, Taichung 40227, Taiwan. PMID: 12524296 [PubMed - in process].

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Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases.

http://actinomycin.4mg.com/ab8.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases. Nucleic Acids Res 2002 Nov 15;30(22):4910-7. Hou MH, Robinson H, Gao YG, Wang AH. Institute of Biological Chemistry, Academia Sinica, Taipei, 115 Taiwan. PMID: 12433994 [PubMed - indexed for MEDLINE].

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Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin d

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Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin d. J Rheumatol 2003 Mar;30(3):550-8. Kim HA, Kim YH, Song YW. Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea. Deoxynivalenol (DON, Vomitoxin). Vomitoxin (Deoxynivalenol, DON, ).

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Actinomycin D

http://actinomycin.4mg.com/ab2.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Induction of surface antigen CD69 expression in T-lymphocytes following exposure to actinomycin D. Int J Immunopharmacol 1999 Oct;21(10):689-703. Morgan CD, Greene JF Jr, Measel JW Jr. PMID: 12609463 [PubMed - in process].

actinomycin.4mg.com

ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells.

http://actinomycin.4mg.com/ab4.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Anticancer Res 2002 Sep-Oct;22(5):2907-11. ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells. Shiono Y, Fujita Y, Oka S, Yamazaki Y. Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan. PMID: 12530016 [PubMed - indexed for MEDLINE].

a23187.4mg.com

Evaluation of the acrosome reaction and viability in buffalo spermatozoa using two staining methods: the effects of heparin and calcium ionophore A23187

http://a23187.4mg.com/a5.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Int J Androl 2002 Aug;25(4):215-22. Evaluation of the acrosome reaction and viability in buffalo spermatozoa using two staining methods: the effects of heparin and calcium ionophore A23187. Kitiyanant Y, Chaisalee B, Pavasuthipaisit K.

a23187.4mg.com

Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187

http://a23187.4mg.com/a3.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. J Helminthol 2003 Mar;77(1):21-6. Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187. Department of Medical Zoology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293.

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Ca2+ uptake and cellular integrity in rat EDL muscle exposed to electrostimulation, electroporation or A23187.

http://a23187.4mg.com/a2.htm

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Am J Physiol Regul Integr Comp Physiol 2003 Mar 6; [epub ahead of print]. Ca2 uptake and cellular integrity in rat EDL muscle exposed to electrostimulation, electroporation or A23187. Gissel H, Clausen T. Department of Physiology, University of Aarhus, DK-8000 Aarhus C, Denmark. Am J Physiol Regul Integr Comp Physiol 2003 Mar 6; [epub ahead of print]. Gissel H, Clausen T.

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ascomycin.4mg.com

Ascomycin Macrolactams fact sheet

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

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Ascomycin, Streptomyces hygroscopicus var ascomyceticus. Soluble in DMSO and Ethanol. Melting Point: 156 -161 degree. Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of FK506 (Tacrolimus) with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant. Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (...

ascomycin.noneto.com

Ascomycin Macrolactams fact sheet

Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Ascomycin macrolactam derivative has been approved for short-term and intermittent long-term therapy in the treatment of mild to moderate atopic dermatitis. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

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