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Mr 280.4 [20350-15-6]. Macrolide antibiotic from Penicillium brefeldianum. Brefeldin Specifically inhibits translocation of proteins from the endoplasmic reticu lum to the Golgi apparatus. Brefeldin A (BFA), a metabolite of the fungus Eupenicillium brefeldianum. Studying mechanisms of protein transport and targeting. Inducing retrograde transport of proteins normally resident in the Golgi into the ER. Blocking protein secretion in many cell types. Toxin in various cell types. Brefeldin A-induced neurotox...
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