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HipHop Lab-Home

The Hip-Hop Chemical Genomics Lab-Research Overview. The primary interests of our lab s research are to screen known and novel anti-proliferatives to:. Understand precise mechanisms of drug action by identifying the major drug target as well off-target effects including those potentially advantageous (for repurposing of approved drugs) and/or detrimental (resulting in unwanted side-effects). To accomplish these aims we will use our well-validated, automated and high-throughput chemogenomic assay, H.

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HipHop Lab-Home | chemogenomics.pharmacy.ubc.ca Reviews
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The Hip-Hop Chemical Genomics Lab-Research Overview. The primary interests of our lab s research are to screen known and novel anti-proliferatives to:. Understand precise mechanisms of drug action by identifying the major drug target as well off-target effects including those potentially advantageous (for repurposing of approved drugs) and/or detrimental (resulting in unwanted side-effects). To accomplish these aims we will use our well-validated, automated and high-throughput chemogenomic assay, H.
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HipHop Lab-Home | chemogenomics.pharmacy.ubc.ca Reviews

https://chemogenomics.pharmacy.ubc.ca

The Hip-Hop Chemical Genomics Lab-Research Overview. The primary interests of our lab s research are to screen known and novel anti-proliferatives to:. Understand precise mechanisms of drug action by identifying the major drug target as well off-target effects including those potentially advantageous (for repurposing of approved drugs) and/or detrimental (resulting in unwanted side-effects). To accomplish these aims we will use our well-validated, automated and high-throughput chemogenomic assay, H.

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chemogenomics.pharmacy.ubc.ca chemogenomics.pharmacy.ubc.ca
1

HIPHOP chemogenomics database

http://chemogenomics.pharmacy.ubc.ca/hiphop

Network of response signatures. HIPHOP: HaploInsufficiency and HOmozygous Profiling. An interactive repository of yeast chemogenomic HIPHOP screens. HIPHOP is a database of small molecule chemogenomic screens performed in S. cerevisiae. In the Giaever and Nislow labs at the Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto ( Lee et al. 2014. Search genes and compounds. Queries can be made by gene or compound. Download all chemogenomic screens.

2

HipHop Lab-Publications

http://chemogenomics.pharmacy.ubc.ca/hiplab/publications.php

Hip-Hop Chemical Genomics Lab-Publications. For more recent publications:. Corey Nislow Google Scholar Citations. Guri Nina Giaever Google Scholar Citations. Lis M, Bhatt S., Schoenly N., Lee A., Nislow C., Bobek L. Chemical Genomic Screening of a Saccharomyces cerevisiae Genomewide Mutant Collection Reveals Genes Required for Defense against Four Antimicrobial Peptides Derived from Proteins Found in Human Saliva. 2013 Feb. 57(2)840-7. 2013 Jan 2. 123(1)315-28. 2013 Jan. 33(1)170-82. Cheung-Ong K., S...

3

HipHop Lab-Home

http://chemogenomics.pharmacy.ubc.ca/hiplab/index.php

The Hip-Hop Chemical Genomics Lab-Research Overview. The primary interests of our lab s research are to screen known and novel anti-proliferatives to:. Understand precise mechanisms of drug action by identifying the major drug target as well off-target effects including those potentially advantageous (for repurposing of approved drugs) and/or detrimental (resulting in unwanted side-effects). To accomplish these aims we will use our well-validated, automated and high-throughput chemogenomic assay, H.

4

HipHop Lab-Research Funding

http://chemogenomics.pharmacy.ubc.ca/hiplab/funding.php

Hip-Hop Chemical Genomics Lab-Research Funding.

5

HipHop Lab-Protocols

http://chemogenomics.pharmacy.ubc.ca/hiplab/protocols.php

Hip-Hop Chemical Genomics Lab-Protocols. Competitive Genomic Screens of Barcoded Yeast Libraries. Follow link to video. Published in the Journal of Visual Experiments explaining the technology. We have developed comprehensive, unbiased genome-wide screens to understand gene-drug and gene-environment interactions. Methods for screening these mutant collections are presented. Robotics- Yeast Growing Robot. Watch Yeast Grower Movie. Quicktime movie, 3.2 MB. ACCESS Robotic Software and DB interface.

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HipHop Lab-Home

The Hip-Hop Chemical Genomics Lab-Research Overview. The primary interests of our lab s research are to screen known and novel anti-proliferatives to:. Understand precise mechanisms of drug action by identifying the major drug target as well off-target effects including those potentially advantageous (for repurposing of approved drugs) and/or detrimental (resulting in unwanted side-effects). To accomplish these aims we will use our well-validated, automated and high-throughput chemogenomic assay, H.

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STANFORD UNIVERSITY SCHOOL OF MEDICINE. The primary interests of our lab’s research are to screen known and novel antiproliferatives to:. Understand precise mechanisms of drug action by identifying the major drug target as well off-target effects including those potentially advantageous (for repurposing of approved drugs) and/or detrimental (resulting in unwanted side-effects). Identify novel, undruggable targets to expand the fraction of the genome that can be exploited for chemotherapeutic intervention.

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