orphanenzymes.org
FAQs - Orphan Enzyme Project
http://www.orphanenzymes.org/faqs
What’s an orphan? Background on orphan enzymes. What is an orphan enzyme? What’s the difference between an orphan and a species-specific orphan? How is it possible that these orphan enzymes weren’t sequenced already? Solving the orphan enzyme problem. How do I report a new orphan enzyme? How do I contribute information about existing orphan enzymes? What if we have a sample of an orphan enzyme and would like to contribute it for sequencing or testing? What is an orphan enzyme? Page for more information.
orphanenzymes.org
What's an orphan? - Orphan Enzyme Project
http://www.orphanenzymes.org/whats-an-orphan-enzyme
What’s an orphan? What’s an orphan? Is an enzyme activity that has been experimentally characterized but for which we lack amino-acid or nucleotide sequence data. When we say that an enzyme activity has been experimentally characterized we mean that at a minimum its reactants and products are known. In most cases, researchers have also identified a wealth of other data such as molecular weights, isoelectric points, reaction kinetics, and more. Been sequenced (the other 75%). Why do orphan enzymes matter?
orphanenzymes.org
Tutorials - Orphan Enzyme Project
http://www.orphanenzymes.org/tutorials
What’s an orphan? Do you have an orphan enzyme, or think you might? Are you interested in learning more about orphan enzymes, including how to find a sequence for yours? Do you have a newly characterized enzyme and I want to make sure all of the information about it is deposited in all the right places? Take a look at the tutorials below for everything from determining if you have an orphan enzyme to how to use data from the literature to find sequences, and more. Is this an orphan enzyme?
orphanenzymes.org
Publications - Orphan Enzyme Project
http://www.orphanenzymes.org/publications
What’s an orphan? Publications from the Orphan Enzymes Project:. Shearer AG, Altman T, Rhee CD. Finding sequences for over 270 orphan enzymes. 9(5): e97250. doi:10.1371/journal.pone.0097250 Click here to read this paper. Ramkissoon K, Miller JK, Ojha S, Watson DS, Bomar MG, Galande AK, Shearer AG. (2013). Rapid identification of sequences for orphan enzymes to power accurate protein annotation. 8(12): e84508. doi:10.1371/journal.pone.0084508 Click here to read this paper. Yamada T, Waller AS,.
orphanenzymes.org
Database - Orphan Enzyme Project
http://www.orphanenzymes.org/database
What’s an orphan? The date files available for download below present orphan enzymes and supporting data collected as part of the work described in our paper Finding sequences for over 270 Orphan Enzymes. Think you have a new orphan enzyme or other information to add to our database? Please let us know by using our contact form. Read our Frequently Asked Questions. Page for guidelines about submitting new orphan enzymes and other updates. Orphan enzyme supporting data. Download the data files.
orphanenzymes.org
People - Orphan Enzyme Project
http://www.orphanenzymes.org/people
What’s an orphan? The Current OEP Team:. Alexander G. Shearer (PI). Former OEP Team Members:. From the research community:. Kristian B. Axelsen. Alexander G. Shearer (PI). Alex comes to the project from Clover Collective. Find Alex’s papers via PubMed. Alex’s personal website. Describing the combined literature, patent, and database search that netted us over 270 orphan sequences. Tomer is currently a grad student in the Biomedical Informatics. Find Tomer’s papers via PubMed. Christine’s work includes de...
orphanenzymes.org
Please take a quick survey about sequence deposition and EC numbers - Orphan Enzyme Project
http://www.orphanenzymes.org/2014/04/16/please-take-quick-survey-sequence-deposition-ec-numbers
What’s an orphan? Please take a quick survey about sequence deposition and EC numbers. In a perfect world, each sequence that is deposited into a resource such as GenBank would have a correct EC number assigned to it. We would love to have your input on some solutions that would make it easier to make sure GenBank and similar entries also get appropriate EC numbers assigned. Please click here to provide your input. Posted in community input. The orphans we find have a big impact. OEP is getting populated.
orphanenzymes.org
News - Orphan Enzyme Project
http://www.orphanenzymes.org/updates
What’s an orphan? New paper – Finding Sequences for over 270 Orphan Enzymes. We’re pleased to announce the publication of our new paper Finding Sequences for over 270 Orphan Enzymes. In this paper, we describe how we used a combined literature, patent, and database evaluation method to find sequences for 275 orphan enzymes. During this research, we learned quite a bit about how orphan enzymes happen. We think we’ve developed some pretty good ways of preventing future orphan enzymes, too. So what’s ...
