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GR Metrics Calculator and Browser

Drug-response studies play an important role in both preclinical and clinical research, but such studies are complicated by differences in cell growth rates across samples and conditions. To improve the value and reliability of such studies, new metrics for parameterizing drug response were developed and published in Nature Methods. Learn More about GR metrics. Upload and analyze your own data. Browse datasets analyzed using GR metrics. Doi: 10.1038/nmeth.3853. Website design and online tool development.

http://www.grcalculator.org/

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GR Metrics Calculator and Browser | grcalculator.org Reviews
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Drug-response studies play an important role in both preclinical and clinical research, but such studies are complicated by differences in cell growth rates across samples and conditions. To improve the value and reliability of such studies, new metrics for parameterizing drug response were developed and published in Nature Methods. Learn More about GR metrics. Upload and analyze your own data. Browse datasets analyzed using GR metrics. Doi: 10.1038/nmeth.3853. Website design and online tool development.
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1 grmetrics
2 reference
3 nat methods
4 nick clark
5 marc hafner
6 michal kouril
7 mario niepel
8 elizabeth williams
9 jeremy muhlich
10 and mario medvedovic
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grmetrics,reference,nat methods,nick clark,marc hafner,michal kouril,mario niepel,elizabeth williams,jeremy muhlich,and mario medvedovic
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GR Metrics Calculator and Browser | grcalculator.org Reviews

https://grcalculator.org

Drug-response studies play an important role in both preclinical and clinical research, but such studies are complicated by differences in cell growth rates across samples and conditions. To improve the value and reliability of such studies, new metrics for parameterizing drug response were developed and published in Nature Methods. Learn More about GR metrics. Upload and analyze your own data. Browse datasets analyzed using GR metrics. Doi: 10.1038/nmeth.3853. Website design and online tool development.

INTERNAL PAGES

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1

General Information

http://www.grcalculator.org/grtutorial

Drug sensitivity and resistance are quantified using IC. Values, but these metrics suffer from a fundamental flaw when applied to growing cells: they are highly sensitive to the number of divisions that take place over the course of a response assay (see the exploration tool below). Division rate varies across cell lines and experimental conditions. The dependency of IC. Are superior to IC. Illustration of the dependency of traditional metrics on division time. Are projected onto the x-axis; E. Are proje...

2

GR Calculator

http://www.grcalculator.org/grcalculator

Open data file (.tsv, .csv). Input with commas as decimal points. URL data file (.tsv, .csv). Load Example (Case A). Control values assigned to treated measurements. Load Example (Case C). Control values stacked with treated measurements. Cap GR values below 1. For offline computation, analysis, and visualization, see the Bioconductor R package. For a step-by-step example of using the GRcalculator, see. To calculate normalized growth rate inhibition (GR) values and corresponding GR metrics:. The input fi...

3

Browse LINCS Dose-Response Datasets

http://www.grcalculator.org/grbrowser

Browse LINCS Dose-Response Datasets. Select Dataset to Browse.

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Explore - HMS LINCS Project

http://lincs.hms.harvard.edu/explore

Library of Integrated Network-based Cellular Signatures. Publication and Project Summaries. Inhibitor Target Space Studies. Experimental and Analytical Methods. Explanation of the HMS LINCS strategy for data collection and release. A public resource for browsing, searching, and downloading HMS LINCS datasets and information about experimental reagents. Publication and Project Summaries. Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs. Lin et al (2015).

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NIH LINCS Program

http://www.lincsproject.org/news

Library of Integrated Network-Based Cellular Signatures. Data and Signature Generation Centers. BD2K-LINCS Data Coordination and Integration Center. Pilot Phase 1 Centers. Data Production and Analysis (U54). Tools & Databases. June 16th, 2016. Sherry Jenkins No Comments. By the Crowd Innovation Lab at Harvard, the Broad Institute, and NIH LINCS Program. The LINCS Center for Transcriptomics. Registration is open at. Http:/ crowdsourcing.topcoder.com/cmap. June 2nd, 2016. Sherry Jenkins No Comments. Side e...

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Tools & Databases - NIH LINCS Program

http://www.lincsproject.org/data/tools-and-databases

Library of Integrated Network-Based Cellular Signatures. Data and Signature Generation Centers. BD2K-LINCS Data Coordination and Integration Center. Pilot Phase 1 Centers. Data Production and Analysis (U54). Tools & Databases. Tools & Databases. BD2K-LINCS Data Coordination and Integration Center. Enrichr is an easy to use intuitive enrichment analysis web-based tool providing various types of visualization summaries of collective functions of gene lists. PMID: 23586463. SEP-L1000 (side effect prediction...

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Publications - NIH LINCS Program

http://www.lincsproject.org/publications

Library of Integrated Network-Based Cellular Signatures. Data and Signature Generation Centers. BD2K-LINCS Data Coordination and Integration Center. Pilot Phase 1 Centers. Data Production and Analysis (U54). Tools & Databases. Milani P, Escalante-Chong R, Shelley BC, Patel-Murray NL, Xin X, Adam M, Mandefro B, Sareen D, Svendsen CN, Fraenkel E (2016). Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells. Nucleic Acids Research pii: gkw377. Sokolo...

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GR Metrics Calculator and Browser

Drug-response studies play an important role in both preclinical and clinical research, but such studies are complicated by differences in cell growth rates across samples and conditions. To improve the value and reliability of such studies, new metrics for parameterizing drug response were developed and published in Nature Methods. Learn More about GR metrics. Upload and analyze your own data. Browse datasets analyzed using GR metrics. Doi: 10.1038/nmeth.3853. Website design and online tool development.

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