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phenomin.fr

Scientific context | PHENOMIN

http://www.phenomin.fr/scientific-context/goals

Genetic Engineering and Model Validation. Ethics and animal welfare. PHENOMIN, as a large scale national infrastructure for Biotechnology and Health, provides services for all French laboratories and is also a major player in the international strategic phenogenomics effort. Implementing mouse genetic engineering,. Securing zootechny, ensuring animal welfare and ethics,. Filling the gap in high-throughput phenotyping by developing new relevant functional assays,. Institut Clinique de la Souris.

phenomin.fr

Training courses | PHENOMIN

http://www.phenomin.fr/training-courses

Genetic Engineering and Model Validation. Ethics and animal welfare. 2d European Advanced School for Mouse Phenogenomics. June 12 - 16, 2017. Would you like to learn how to choose, create and analyse your best mouse model? Do you have a sufficient background in mouse functional genomics to lead as best your research? 24 experts from European landscape will be present to. Exchange and discuss your major on-going works, scientific and methodological issues. We encourage both industrial and academic. Https:...

phenomin.fr

Services | PHENOMIN

http://www.phenomin.fr/services/genetic-engineering-and-model-validation

Genetic Engineering and Model Validation. Ethics and animal welfare. Genetic Engineering and Model Validation. Genetic Engineering 150 vectors per year. Knock-out constitutive, conditional. Knock-out tissues specific and/or inducible. Knock-in, genetic targeted insertion :. Point mutation, complex and multi-allelic modifications, reporter Tag (Rosa26, HPRT, Random transgenesis,.), depletion of cell types (hDTR, DTa chains,.), interactoms, cell tracking. Nuclease genome engineering (CRISPR/Cas9 or TALEs).

phenomin.fr

Services | PHENOMIN

http://www.phenomin.fr/services/zootechny

Genetic Engineering and Model Validation. Ethics and animal welfare. Maintaining the expected health status of your animal colonies is vital to achieve valid and reproducible research results. PHENOMIN provides a controlled and reliable environment for mice and rats breeding. Health status assessment / Individual housing Capacity: 5 isolators and 120 IVC. From any worldwide facilities. Dedicated isolators or Individually Ventilated Cages (IVC). Quarantine to establish a reliable sanitary diagnosis. Full-...

phenomin.fr

Services | PHENOMIN

http://www.phenomin.fr/services

Genetic Engineering and Model Validation. Ethics and animal welfare. PHENOMIN, as a large scale national infrastructure for Biotechnology and Health, provides services for all French laboratories. PHENOMIN offers 37 different services. CRISPR Mediated REarrangement (CRISMERE) strategy. The CRISPR / Cas9 "revolution". Discovered in 2012, the technique known as "CRISPR / Cas9" allows to target DNA very precisely through a guide RNA. The latter is associated with an enzyme, Cas9, which makes it possible...

phenomin.fr

Scientific context | PHENOMIN

http://www.phenomin.fr/scientific-context/workpackages

Genetic Engineering and Model Validation. Ethics and animal welfare. WP2: Genetic Engineering and Model Validation. Some of the resources to be developed under WP2 will also be of interest for pharmaceutical or biotech companies and will thus provide additional funding for the nodes. Phenotyping protocols will be transferred to PhenoPro to extend the offer of this ICS spin out. Two main scientific achievements are anticipated:. To develop innovative and pertinent genetic tools for the scientific community.

phenomin.fr

Services | PHENOMIN

http://www.phenomin.fr/services/resources-and-tools

Genetic Engineering and Model Validation. Ethics and animal welfare. Mouse Nuclear Receptor Zoo. Mouse models for rare diseases. FAQ Crispr ROCAD-CELPHEDIA.pdf (828.2 KB). Gene expression Database: MousePat. Cryopreservation: EMMA mouse resources. Library of tracking tools (reporter/tag). Institut Clinique de la Souris. Transgénèse et Archivage dAnimaux Modèles. Genetic Engineering and Model Validation. Genetic Engineering and Model Validation. Ethics and animal welfare.

phenomin.fr

Scientific context | PHENOMIN

http://www.phenomin.fr/scientific-context

Genetic Engineering and Model Validation. Ethics and animal welfare. Biology is facing a revolution, moving from a research centered on small groups to the use of large-scale infrastructures. Large-scale infrastructures permit to integrate sophisticated and diverse methods and protocols and also to preserve such continuous expertise and know-how for tackling the complex issues biologists are faced with. Institut Clinique de la Souris. Transgénèse et Archivage dAnimaux Modèles. Ethics and animal welfare.

phenomin.fr

Rare Diseases | PHENOMIN

http://www.phenomin.fr/rare-diseases

Genetic Engineering and Model Validation. Ethics and animal welfare. Mouse Models for Rare Diseases. Successful long term collaborations with French and European partners ( Fondation maladies rares. Allowed generation of customed mouse models for researchers. Investigating gene function and human pathophysiology. More than 50 mouse rare disease models are now available for your research. For more details concerning the alleles, please contact us. By orthologous gene and by shared phenotypic features.

phenomin.fr

Calls for proposals | PHENOMIN

http://www.phenomin.fr/calls/previous-calls

Genetic Engineering and Model Validation. Ethics and animal welfare. We are glad to announce the new PHENOMIN call dedicated to generation and characterization of CreER T2. Cell specific promoter driven deleter mouse lines. Since 2011, PHENOMIN has generated more than 150 models with conditional potential. In the frame of the International Mouse Phenotyping Consortium (IMPC). More than 5,000 genes are already committed to the IMPC pipeline. Most of these models can be driven in conditional alleles. Lines...