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The sphingolipids in Cancer and Aging Lab. UNDERSTANDING SPHINGOSINE 1-PHOSPHATE METABOLISM IN CANCER and AGING. January 27, 2014. Sphingosine kinase-2 expression and localization is altered in Alzheimer’s Disease. In a cohort of 25 post-mortem brain tissues from Alzheimer's disease patients, our results show a correlation between amyloid deposits and a loss of cytosolic SphK2 expression associated with a rise of nuclear cleaved SphK2. By Gaëlle Dominguez et al. in. January 18-19, 2018. July 6-7, 2017.

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The sphingolipids in Cancer and Aging Lab. UNDERSTANDING SPHINGOSINE 1-PHOSPHATE METABOLISM IN CANCER and AGING. January 27, 2014. Sphingosine kinase-2 expression and localization is altered in Alzheimer’s Disease. In a cohort of 25 post-mortem brain tissues from Alzheimer's disease patients, our results show a correlation between amyloid deposits and a loss of cytosolic SphK2 expression associated with a rise of nuclear cleaved SphK2. By Gaëlle Dominguez et al. in. January 18-19, 2018. July 6-7, 2017.

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WELCOME | iSphingo | isphingo.com Reviews

https://isphingo.com

The sphingolipids in Cancer and Aging Lab. UNDERSTANDING SPHINGOSINE 1-PHOSPHATE METABOLISM IN CANCER and AGING. January 27, 2014. Sphingosine kinase-2 expression and localization is altered in Alzheimer’s Disease. In a cohort of 25 post-mortem brain tissues from Alzheimer's disease patients, our results show a correlation between amyloid deposits and a loss of cytosolic SphK2 expression associated with a rise of nuclear cleaved SphK2. By Gaëlle Dominguez et al. in. January 18-19, 2018. July 6-7, 2017.

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isphingo.com

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Clinical Studies | iSphingo

http://www.isphingo.com/page18

The Sphingolipids in Cancer and Aging Lab. BACK TO WELCOME PAGE. Enhanced SphK1 and reduced S1P lyase expression and activity demonstrate deregulated S1P metabolism in prostate cancer. In our initial study (Malavaud et al, Eur J Cancer, 2010), we reported the first-in-man study of quantification of SphK1 enzymatic activity in cancer. Using fresh tissues retrieved from 28 patients undergoing radical prostatectomy, we assessed SphK1 enzymatic activity in tumor and normal counterpart for each patient. Paraf...

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Lab Alumni | iSphingo

http://www.isphingo.com/page19

The Sphingolipids in Cancer and Aging Lab. BACK TO WELCOME PAGE. Lecturer, Imperial College, London, UK. Assistant Professor, ICBMS CNRS UMR 5246, Lyon, FR. Inserm Associate Scientist, StromaLab, Toulouse, FR. Professor of Pathology, Institut Universitaire du Cancer Oncopôle, Toulouse, FR. Business development and Technology Transfer consultant, Bioindustry park Silvano Fumero, Torino, IT. Current position : Postdoctoral Fellow at the Boston University School of Medicine, Boston, USA.

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Chemoprevention | iSphingo

http://www.isphingo.com/page15

The Sphingolipids in Cancer and Aging Lab. BACK TO WELCOME PAGE. Of this class of compounds,. Clinical studies have shown the usefulness of green tea polyphenols on prostate cancer chemoprevention. More information about nutrition, lifestyle strategies and prostate cancer can be found at :. SphK1/S1P signaling is a molecular target of polyphenols. Our results establish that SphK1 is a downstream effector of the ERK/Phospholipase D (PLD) signaling cascade, which is inhibited by green tea and wine polyphen...

4

Response to therapies | iSphingo

http://www.isphingo.com/page2

The Sphingolipids in Cancer and Aging Lab. BACK TO WELCOME PAGE. The sphingolipid metabolites, ceramide, sphingosine and sphingosine 1-phosphate (S1P) play crucial roles as signaling molecules in physio(patho)logy. Two of these sphingolipids, ceramide and S1P, have received particularly significant attention since the mid-1990s as critical mediators of cell death or survival. Click here for review. Click here for review. Notwithstanding, ceramide and sphingosine are interconvertible metabolites and it is...

5

Hypoxia | iSphingo

http://www.isphingo.com/page6

The Sphingolipids in Cancer and Aging Lab. BACK TO WELCOME PAGE. From J. Martin Brown and William R. Wilson Nature Reviews Cancer 4, 437-447. Studies demonstrating the importance of HIFs expression for tumor survival have made HIFs as attractive targets for cancer therapy. SphK1/S1P signaling regulates HIF-1 level and activity in multiple cancer cell models. SphK1 activation invariably preceding HIF-1α accumulation. Read the full story. Cancer Res, 2008. Staining of representative regions of tumor sectio...

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imodi-cancer.org

CNRS – Imodi-cancer

http://www.imodi-cancer.org/organisation/cnrs

Strengths and operating rules. Expertises & plateforms. Notre participation au projet IMODI permettra la caractérisation pharmacologique d’une collection de tumeurs prostatiques, aux fins d’évaluation et de validation de thérapies anticancéreuses (suppression androgénique, chimiothérapies, radiothérapies, thérapeutiques ciblées) en cultures cellulaires (2D, sphéroïdes) et in vivo (tumeurs primaires orthotopiques et métastases osseuses). Les caractérisations omics réalisées au sein de la filière nous ...

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WELCOME | iSphingo

The sphingolipids in Cancer and Aging Lab. UNDERSTANDING SPHINGOSINE 1-PHOSPHATE METABOLISM IN CANCER and AGING. January 27, 2014. Sphingosine kinase-2 expression and localization is altered in Alzheimer’s Disease. In a cohort of 25 post-mortem brain tissues from Alzheimer's disease patients, our results show a correlation between amyloid deposits and a loss of cytosolic SphK2 expression associated with a rise of nuclear cleaved SphK2. By Gaëlle Dominguez et al. in. January 18-19, 2018. July 6-7, 2017.

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