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Projects of SUMO signaling group
http://www.biochem2.com//sumosg/projects.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Mechanistic and functional aspects of SUMO-SIM interactions. Signaling by SUMO relies on the recognition of the post-translational mark by specialized interaction modules termed SUMO interaction motifs (SIMs). SUMO-mediated protein/protein interactions are frequently mediated by the non-covalent binding of SUMO conjugates to SIMs in a binding partner. The SUMO system in mammalian ribosome biogenesis. Ribosome biogenesis is a tightly controlled pathway that...
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Members of Autophagy signaling group
http://www.biochem2.com//asg/people.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Christian Behrends was born in Frankfurt, Germany. He studied Biology at the University of Konstanz and obtained his diploma degree in 2001 after completing his diploma thesis in the lab of M. Ehrmann at the Cardiff School of Bioscience, Cardiff, UK. Mira comes from a big family with three elder brothers and enjoys all kinds of sports, especially cycling, skiing, and climbing. She is also a proud owner of two cats back in Ljubljana, one of them soon re...
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Projects of Cardiovascular signaling group
http://www.biochem2.com//cvsg/projects.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Intracellular trafficking of endothelial nitric oxide synthase function of NOSTRIN. Figure 1: Modular structure of NOSTRIN. Figure 2: Colocalization of NOSTRIN, caveolin and dynamin in CHO-eNOS cells expressing. One protein many functions? Function and physiological role of NOSIP, a nitric oxide synthase interacting protein. Implications of NO reactivity. Localization of endothelial nitric oxide synthase. Dynamic regulation of NOSIP. Recent results indicat...
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Projects of Ubiquitin signaling group
http://www.biochem2.com//usg/projects.html
Funding and Top Pubs. Wahlfach Leben und Leiden. In eukaryotes, selective protein degradation is performed primarily by the ubiquitin-proteasome system (UPS). The 26S proteasome is a huge macromolecular complex composed of proteolytically active 20S core particle (CP) capped at one or both ends by a 19S regulatory particle (RP). The RP recognizes ubiquitinated substrates, deconjugates ubiquitin chains, and unfolds substrates before their translocation into the CP.
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Institute of Biochemistry II - Molecular Cell Biology - Projects
http://www.biochem2.com//mcb/projects.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Control of deubiquitinating enzymes (DUBs). Regulation of autophagy by deubiquitinating enzymes (DUBs). Our project aims to characterize DUBs that are indispensable for the correct course of autophagy. A mass spectrometry-based interactome analysis revealed interactions between several DUBs and regulators or constituents of the autophagy machinery. We are characterizing the impact of these enzymes on autophagy induction, autophagosome biogenesis, a...
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Institute of Biochemistry II - Structural Biology Lab
http://www.biochem2.com//sbl/people.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Masato obtained his PhD in 2007 from The Graduate University for Advanced Studies, Japan. For his post-doctoral studies, Masato moved to The Structural Genomics Consortium, University of Toronto, Canada and MRC - Laboratory of Molecular Biology, Cambridge, UK where he worked on the structure of deubiquitinase. He was postdoctoral Fellow in the laboratory of Professor Ivan Dikic until he started his group in 2013. Read More.
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Members of Cardiovascular signaling group
http://www.biochem2.com//cvsg/people.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Meike Hoffmeister studied biology in Oldenburg and received a PhD in biology from the University of Düsseldorf in 2004. Meike joined the Institute of Biochemistry II as a postdoctoral fellow in 2005 and focused her research interests on signalling processes in the cardiovascular system. Since 2009, Meike is a staff scientist in the group of Stefanie Oess and studies signal transduction mechanisms in cardiovascular disease and development.
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Members of Sumo signaling group
http://www.biochem2.com//sumosg/people.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Stefan Müller was born in Augsburg, Germany. He studied pharmacy at Ludwig-Maximilians-University Munich and obtained his diploma and approbation in 1991. He subsequently worked as a Ph.D. student and research assistant in the Institute of Physiological Chemistry at Hamburg University under the supervision of Prof. Seitz and graduated in 1995. In 2010 he was appointed W2 professor in biochemistry at IBCII. Read More. After completing her PhD thesis she kep...
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Projects of Molecular signaling group
http://www.biochem2.com//molsig/projects.html
Funding and Top Pubs. Wahlfach Leben und Leiden. EGF receptor endocytosis and degradation. Figure 1. Members of the Cbl protein family. Domain structure of mammalian Cbl, Cbl-b and Cbl-c, Drosophila melanogaster D-Cbl short and long as well as Caenorhabditis elegans SLI-1 are shown. Figure 2. Intracellular trafficking of activated receptors. Ubiquitin signals in inflammatory pathways. Our recent discovery of linear-ubiquitin chain recognition by NEMO was very striking because it was totally different fro...
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Members of Protein Engineering group
http://www.biochem2.com//peg/people.html
Funding and Top Pubs. Wahlfach Leben und Leiden. Svenja studied biology at Technische Universität Darmstadt. Her diploma thesis was about affinity maturation of a scFv-antibody using phage display with Prof. Harald Kolmar as her supervisor. In September 2013 she started her PhD in the Protein Engineering Group of Andreas Ernst at the Institute of Biochemistry II. Currently Svenja is studying the Ras signaling pathway. Read More. Human Biology and Bioimaging. May - Dec 2014.
