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MCCA - Mouse Clinic for Cancer and Aging

Aging and Phenotyping facility. MCCA: Mouse Clinic for Cancer and Aging. The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘ healthy aging. The Netherlands Cancer Institute ( NKI. And the European Research Institute for the Biology of Aging ( ERIBA. The MCCA houses four key expertises:. A Mouse Imaging facility for both functional and anatomical imaging. Proje...

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MCCA - Mouse Clinic for Cancer and Aging | mccanet.nl Reviews

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Aging and Phenotyping facility. MCCA: Mouse Clinic for Cancer and Aging. The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘ healthy aging. The Netherlands Cancer Institute ( NKI. And the European Research Institute for the Biology of Aging ( ERIBA. The MCCA houses four key expertises:. A Mouse Imaging facility for both functional and anatomical imaging. Proje...

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2 menu

3 about mcca

4 managing directors

5 organization of mcca

6 transgenic facility

7 services offered

8 gemm esc archive

9 relevant publications

10 mouse cancer clinic

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MCCA - Mouse Clinic for Cancer and Aging | mccanet.nl Reviews

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Aging and Phenotyping facility. MCCA: Mouse Clinic for Cancer and Aging. The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘ healthy aging. The Netherlands Cancer Institute ( NKI. And the European Research Institute for the Biology of Aging ( ERIBA. The MCCA houses four key expertises:. A Mouse Imaging facility for both functional and anatomical imaging. Proje...

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mccanet.nl

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MCCA - Mouse Clinic for Cancer and Aging

http://www.mccanet.nl/services-offered.html

Aging and Phenotyping facility. In consultation with the researcher we provide advice on the strategy and construct design for generating the mouse strain tailor-made to answer a biological question using the GEMM-ESC pipeline. Depending on the complexity and workload a practical plan is devised to reach that goal and in some case might involve participation of the researcher in cloning and/or ESC culture. Our services are listed below and include cryopreservation of new and existing strains.

2

MCCA - Mouse Clinic for Cancer and Aging

http://www.mccanet.nl/publications-of-facility-aging.html

Aging and Phenotyping facility. Verovskaya E, Broekhuis MJ, Zwart E, Weersing E, Ritsema M, Bosman LJ, van Poele T, de Haan G, Bystrykh LV. (2014) Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines. J Exp Med. 10;211(3):487-97. Geiger H, de Haan G, Florian MC. (2013) The ageing haematopoietic stem cell compartment. Nature Reviews Immunology 13(5):376-89. Curr Opin Immunol. 23(4):512-7. Aging and Phenotyping Facility. 31 (0)50 363 2998.

3

MCCA - Mouse Clinic for Cancer and Aging

http://www.mccanet.nl/services-mouse-imaging-unit.html

Aging and Phenotyping facility. The MCCA Imaging Unit offers a full service package for researchers interested in incorporating imaging into their research. The services offered consist of the following:. Nuclear imaging: Radiotracers are obtained through the nuclear medicine department. Depending on the tracer, either PET/CT or SPECT/CT can be used. 31 (0)20 512 7485.

4

MCCA - Mouse Clinic for Cancer and Aging

http://www.mccanet.nl/description-of-facility.html

Aging and Phenotyping facility. The MCCA Transgenic facility provides the typical services related to the generation and cryopreservation of mutant mouse strains, such as construct design, Embryonic Stem Cell (ESC) culture, micro-injection and sperm cryopreservation. On top of that we have developed a new pipeline for the fast and easy modification of existing Genetically Engineered Mouse Models (GEMMs), called the GEMM-ESC strategy ( Huijbers et al., Nature Protocols 2015. 1) Fast modification of comple...

5

MCCA - Mouse Clinic for Cancer and Aging

http://www.mccanet.nl/services-offered-mouse.html

Aging and Phenotyping facility. Testing novel compounds or their combination in new generation mouse models for cancer. Multimodal in vivo imaging of tumor growth and therapy response. Establishing pharmacokinetics and dynamics of novel drugs or drug combination. Projects are initiated on a collaborative basis. Marieke van de Ven PhD. 31 (0)20 512 2086.

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biomedicalgenetics.nl

Cancer Genomics Center - Links

http://www.biomedicalgenetics.nl/links

Summer School Utrecht University. University Medical Centre Utrecht: UMCU. Hubrecht Institute for Developmental Biology and Stem Cell Research: Hubrecht. Netherlands Cancer Institute: NKI. Erasmus Medical Center Rotterdam: Erasmus MC. Academic Medical Center Amsterdam: AMC. Leiden University Medical Centre: LUMC. Radboud University Medical Center Nijmegen: Radboud UMC. Centre for Personalized Cancer Treatment: CPTC. Centre for Genome Diagnostics: CGD. Cancer Systems Biology Centre: CSBC.

cancergenomics.nl

Cancer Genomics Center - Links

http://www.cancergenomics.nl/links

Summer School Utrecht University. University Medical Centre Utrecht: UMCU. Hubrecht Institute for Developmental Biology and Stem Cell Research: Hubrecht. Netherlands Cancer Institute: NKI. Erasmus Medical Center Rotterdam: Erasmus MC. Academic Medical Center Amsterdam: AMC. Leiden University Medical Centre: LUMC. Radboud University Medical Center Nijmegen: Radboud UMC. Centre for Personalized Cancer Treatment: CPTC. Centre for Genome Diagnostics: CGD. Cancer Systems Biology Centre: CSBC.

infrafrontier.eu

NKI GEMM-ESC archive - Infrafrontier

https://www.infrafrontier.eu/resources-and-services/access-emma-mouse-resources/nki-gemm-esc-archive

International collaborations and projects. European research policy context. INFRAFRONTIER Preparatory Phase project. Deposit mice into the EMMA repository. Access to EMMA mouse resources. GenOway EUCOMM KO models. EMMA axenic (germ-free) service. Free of charge Transnational Access services. Training and consulting services. EMMA repository conditions and MTAs. EMMA policy on licensing and use restriction. Animal welfare and ethics. EU and national regulations for animal experimentation. Currently the G...

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MCCA - Mouse Clinic for Cancer and Aging

Aging and Phenotyping facility. MCCA: Mouse Clinic for Cancer and Aging. The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘ healthy aging. The Netherlands Cancer Institute ( NKI. And the European Research Institute for the Biology of Aging ( ERIBA. The MCCA houses four key expertises:. A Mouse Imaging facility for both functional and anatomical imaging. Proje...

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