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HL Disease Awareness - Relapse - No Good Cancer

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HL Disease Awareness - Relapse - No Good Cancer | nogoodcancer.com Reviews
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4 survival after transplant
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8 seattle genetics and
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HL Disease Awareness - Relapse - No Good Cancer | nogoodcancer.com Reviews

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1

HL Disease Awareness - Survival After Transplant - No Good Cancer

http://www.nogoodcancer.com/hl-survival.php

Transplantation does not extend survival in all cases. High-dose therapy with autologous stem cell transplant (HDT/ASCT) is often the best option for relapsed or refractory disease, but there are no data supporting an extension in overall survival (OS) with ASCT. Approximately 50% of patients relapse after ASCT,. And two-thirds of relapsed patients will die within 5 years. Forty-five percent of patients who relapse following ASCT will die within 2 years.

2

HL Disease Awareness - HL References - No Good Cancer

http://www.nogoodcancer.com/hl-references.php

Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. Sibon D, Brice P. Optimal treatment for relapsing patients with Hodgkin lymphoma. Expert Rev Hematol. Diehl V, Re D, Harris NL, Mauch PM. Hodgkin lymphoma. In: DeVita VT Jr, Lawrence TS, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. Vol 2 8th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2008:2167-2220. Canellos GP. Relapsed and refractory Hodgkin’s lymphoma: new avenues? Hematol Oncol Clin North Am.

3

HL Disease Awareness - Elderly Patients - No Good Cancer

http://www.nogoodcancer.com/hl-elderly.php

Outcomes are poor for elderly patients with HL. Elderly patients have poorer outcomes than younger patients, including higher rates of relapse and lower rates of complete remission, progression-free survival and overall survival (Figure 3). They often cannot tolerate intensive therapy due to frailty or comorbidities, and less-intensive regimens are less effective. In addition, patients over 60 years of age are often underrepresented in clinical trials, further reducing their options.

4

HL Disease Awareness - Late Complications - No Good Cancer

http://www.nogoodcancer.com/hl-complications.php

Late health complications in young patients. Young patients have high survival rates but long-term health complications, including secondary malignancies and cardiovascular disease (Figure 1). Currently, treatment-related, long-term toxicity kills more patients than uncontrolled HL. The risk for breast cancer is increased 37-fold in women surviving pediatric HL. Clinical trials are now focusing on minimizing the intensity of treatment to avoid late, potentially fatal toxic effects.

5

HL Disease Awareness - Relapse - No Good Cancer

http://www.nogoodcancer.com/index.php

Even with effective frontline therapy, approximately one-third of patients relapse. Hodgkin lymphoma (HL) is globally viewed as a cancer success story; however, it is estimated that over 1,300 Americans died from HL in 2010 (Table 1). Up to 10% of cases are refractory to conventional therapy,. And up to 30% will relapse after an initial complete response. For patients with a poor prognosis (International Prognostic Score [IPS] ≥4), the relapse rate exceeds 40%.

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HL Disease Awareness - Relapse - No Good Cancer

Even with effective frontline therapy, approximately one-third of patients relapse. Hodgkin lymphoma (HL) is globally viewed as a cancer success story; however, it is estimated that over 1,300 Americans died from HL in 2010 (Table 1). Up to 10% of cases are refractory to conventional therapy,. And up to 30% will relapse after an initial complete response. For patients with a poor prognosis (International Prognostic Score [IPS] ≥4), the relapse rate exceeds 40%.

nogoodcancer.info nogoodcancer.info

HL Disease Awareness - Relapse - No Good Cancer

Even with effective frontline therapy, approximately one-third of patients relapse. Hodgkin lymphoma (HL) is globally viewed as a cancer success story; however, it is estimated that over 1,300 Americans died from HL in 2010 (Table 1). Up to 10% of cases are refractory to conventional therapy,. And up to 30% will relapse after an initial complete response. For patients with a poor prognosis (International Prognostic Score [IPS] ≥4), the relapse rate exceeds 40%.

nogoodcancer.net nogoodcancer.net

HL Disease Awareness - Relapse - No Good Cancer

Even with effective frontline therapy, approximately one-third of patients relapse. Hodgkin lymphoma (HL) is globally viewed as a cancer success story; however, it is estimated that over 1,300 Americans died from HL in 2010 (Table 1). Up to 10% of cases are refractory to conventional therapy,. And up to 30% will relapse after an initial complete response. For patients with a poor prognosis (International Prognostic Score [IPS] ≥4), the relapse rate exceeds 40%.

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HL Disease Awareness - Relapse - No Good Cancer

Even with effective frontline therapy, approximately one-third of patients relapse. Hodgkin lymphoma (HL) is globally viewed as a cancer success story; however, it is estimated that over 1,300 Americans died from HL in 2010 (Table 1). Up to 10% of cases are refractory to conventional therapy,. And up to 30% will relapse after an initial complete response. For patients with a poor prognosis (International Prognostic Score [IPS] ≥4), the relapse rate exceeds 40%.

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