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NFATc-Down's Syndrome - Home

Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. Figure 1: Child with Down's Syndrome. Figure 2: Human chromosomes. NFAT describes a family of transcription factors that are responsible for the control of important cell processes including differentiation. It has been shown that mice who lack NFATc die from an inability to form cardiac valves. (3). NFATc and Down's Syndrome. 2 Nemours Foundation (1995-2009). Down Syndrome. 3 Ranger et al.

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NFATc-Down's Syndrome - Home | nollgen677s09.weebly.com Reviews

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. Figure 1: Child with Down's Syndrome. Figure 2: Human chromosomes. NFAT describes a family of transcription factors that are responsible for the control of important cell processes including differentiation. It has been shown that mice who lack NFATc die from an inability to form cardiac valves. (3). NFATc and Down's Syndrome. 2 Nemours Foundation (1995-2009). Down Syndrome. 3 Ranger et al.

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1 nfatc down's syndrome

2 site menu

3 popular press review

4 scientific article review

5 popular vs scientific

6 the gene

7 phenotypes/gene ontology

8 chemical genetics

9 protein data

10 protein network

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NFATc-Down's Syndrome - Home | nollgen677s09.weebly.com Reviews

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. Figure 1: Child with Down's Syndrome. Figure 2: Human chromosomes. NFAT describes a family of transcription factors that are responsible for the control of important cell processes including differentiation. It has been shown that mice who lack NFATc die from an inability to form cardiac valves. (3). NFATc and Down's Syndrome. 2 Nemours Foundation (1995-2009). Down Syndrome. 3 Ranger et al.

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Chemical Genetics - NFATc-Down's Syndrome

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. The discovery of FK506 binding as a molecular function in the gene ontology of NFATc lead to a search for a better understanding of this relationship. A query of FK506 on DrugBank. Was completed with the following results:. The molecular formula of FK506 (or Tacrolimus) is. Chemical Structure of FK506. Http:/ www.drugbank.ca/search/seqquery. Margaret Noll, mnoll@wisc.edu.

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Misc. Data - NFATc-Down's Syndrome

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. After observing the other projects that were completed this semester other important interacting proteins were uncovered that were not observed in the original analysis. These proteins were FOXP2, which is involved in development of normal speech patterns, and GSK3B, a protein involved in pathways important to normal cardiovascular development. A STRING. Http:/ string.embl.de/.

3

Protein Network - NFATc-Down's Syndrome

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. Above is an example of a protein network, in humans, involving NFATc, which was obtained using STRING. A few familiar proteins can be seen in the diagram including CALN and DSCR1 which were both discussed as to their effects on NFATc in the Arron et al. Paper discussed in the Scientific Article Review. It is not surprising that interleukin precursors would be known to interact with NFATc.

4

Popular Press Review - NFATc-Down's Syndrome

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. In June 2006, the Phg foundation released an article, by Dr. Ireena Dutta, entitled "Down's Syndrome and the role of the NFAT signaling pathway." This article is a review of a paper put out by Arron et al. NFAT dysregulation by increase dosage of DSCR1 and DYRK1A on chromosome 21", published in Nature (also in 2006). The review praises Arron et al. Picture retrieved from referenced website.

5

The Gene - NFATc-Down's Syndrome

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Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. The nucleotide sequence for NFATc was obtained from the NCBI website. The sequence in humans is found to be 76117153 base pairs in length and can also be know as: NFAT2, NF-ATC, MGC138448, NFATC1. The NFATc coding sequence resides on the 18th chromosome. There are five know isoforms for NFATc and the full sequence to Isoform B is represented through this sequence link. Family signature&#46...

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NFATc-Down's Syndrome - Home

Conclusions and Future Directions. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009. Figure 1: Child with Down's Syndrome. Figure 2: Human chromosomes. NFAT describes a family of transcription factors that are responsible for the control of important cell processes including differentiation. It has been shown that mice who lack NFATc die from an inability to form cardiac valves. (3). NFATc and Down's Syndrome. 2 Nemours Foundation (1995-2009). Down Syndrome. 3 Ranger et al.

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