pacdb.org

Pharmacogenetics Database

We have developed a Pharmacogenetics-Cell line database for use as a central repository of pharmacology-related phenotypes that integrates genotypic, gene expression, and pharmacological data obtained via lymphoblastoid cell lines. Since genetic polymorphisms may impact a drug response phenotype through either gene expression or through their effects on miRNA, Affymetrix. Human Exon Array 1.0 expression data from 90 CEU and 90 YRI LCLs as well as Exiqon. The database provides results from:. 169; 2009 PAAR.

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Pharmacogenetics Database | pacdb.org Reviews

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We have developed a Pharmacogenetics-Cell line database for use as a central repository of pharmacology-related phenotypes that integrates genotypic, gene expression, and pharmacological data obtained via lymphoblastoid cell lines. Since genetic polymorphisms may impact a drug response phenotype through either gene expression or through their effects on miRNA, Affymetrix. Human Exon Array 1.0 expression data from 90 CEU and 90 YRI LCLs as well as Exiqon. The database provides results from:. 169; 2009 PAAR.

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Pharmacogenetics Database | pacdb.org Reviews

https://pacdb.org

We have developed a Pharmacogenetics-Cell line database for use as a central repository of pharmacology-related phenotypes that integrates genotypic, gene expression, and pharmacological data obtained via lymphoblastoid cell lines. Since genetic polymorphisms may impact a drug response phenotype through either gene expression or through their effects on miRNA, Affymetrix. Human Exon Array 1.0 expression data from 90 CEU and 90 YRI LCLs as well as Exiqon. The database provides results from:. 169; 2009 PAAR.

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pacdb.org

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Pharmacogenetics Database

http://www.pacdb.org/index1.html

Utilizing LCLs for pharmacogenetic discovery or validation are listed. Examples of database usage:. Querying differential expression between YRI and CEU populations for a gene (or genes) of interest (via transcript cluster ID). Querying SNPs important in the cytotoxicity of one drug to see if those SNPs are important in the cytotoxicity of cell lines to any other drugs. Usage, in connection with the SCAN. Querying exon-level (probeset) expression to evaluate PCR performance prior to primer-probe design.

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Pharmacogenetics Database

http://www.pacdb.org/index_pharma.html

Cytotoxicity / Genotype Association. Gene Expression / Phenotype Association. Cytotoxicity / Genotype Association. 1) CEPH - from northern and western Europe . . . 2) Yoruba in Ibadan, Nigeria. P-value of differential expression:. Permuted p-values of differential expression:. Upper = one-sided p-value for CEU YRI. Lower = one-sided p-value for CEU. Upload Transcript Cluster list:. Enter q-value threshold for differential expression:. Expression / Phenotype Information. Upload Transcript Cluster list:.

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Pharmacogenetics Database

http://www.pacdb.org/references.html

Peer-reviewed Publications: PAAR-Dolan 2005-2009. Liu W, Innocenti F., Wu M.H., Desai A., Dolan M.E., Cook E.H., Ratain, M.J. A functional common polymorphism in an Sp1 recognition site of the epidermal growth factor receptor gene promoter. Cancer Res. 65:46-53, 2005. PMID 15665278. Zhang, W., Bleibel, W.K., Roe, C.R., Cox, N.J., Dolan, M.E. Gender-specific Differences in Expression in Lymphoblastoid Cell Lines. Pharmacogenetics and Genomics. 17: 447-450, 2007. PMID 17502836. Huang, R.S., Duan, S...Huang...

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Pharmacogenetics Database

http://www.pacdb.org/resources.html

The aim of PACdb. Is to aid researchers in understanding how genetic variation contributes to differences in drug response and cytotoxicity. Is a database of pharmacology-related phenotypes that integrates genotypic and gene expression data. Whole Genome Analysis of Genotype and Cytotoxicity Association. SNP genotypes were downloaded from the International HapMap. Database. SNPs with evidence of Mendelian allele transmission errors and those with a minor allele frequency. Linkage Disequilibrium (LD) info...

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Pharmacogenetics Database

http://www.pacdb.org/help.html

What is the source of the information served on the PACdb database? How and by whom is PACdb going to be maintained? PACdb will be maintained and kept up to date by the Pharmacogenetics of Anticancer Agents Research Group based at the University of Chicago, which is funded by the NIHGMS U0161393. What are your immediate plans for PACdb? In order to encourage the development of bioinformatics applications that utilize or integrate the data served on PACdb, we are developing an application programming inte...

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Pharmacogenetics Database

We have developed a Pharmacogenetics-Cell line database for use as a central repository of pharmacology-related phenotypes that integrates genotypic, gene expression, and pharmacological data obtained via lymphoblastoid cell lines. Since genetic polymorphisms may impact a drug response phenotype through either gene expression or through their effects on miRNA, Affymetrix. Human Exon Array 1.0 expression data from 90 CEU and 90 YRI LCLs as well as Exiqon. The database provides results from:. 169; 2009 PAAR.

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