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PROBER.CSHL.EDU

PROBER is an oligonucleotide primer design software application that can generate highly specific probes for use in fluorescence in-situ hybridization ( FISH. And other in-situ labeling methods by densely tiling relatively small genomic intervals. Prober was written in C# 2005 and has sub-programs that are complied as executables that were written in c, perl and splus. When running PROBER you will need to have the .net framework 2.0. Installed on your pc machine. Cold Spring Harbor Laboratory.

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PROBER.CSHL.EDU | prober.cshl.edu Reviews
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PROBER is an oligonucleotide primer design software application that can generate highly specific probes for use in fluorescence in-situ hybridization ( FISH. And other in-situ labeling methods by densely tiling relatively small genomic intervals. Prober was written in C# 2005 and has sub-programs that are complied as executables that were written in c, perl and splus. When running PROBER you will need to have the .net framework 2.0. Installed on your pc machine. Cold Spring Harbor Laboratory.
<META>
KEYWORDS
1 new version released
2 in silico
3 in vitro
4 nicholas
5 navin
6 wigler lab
7 navin@cshl edu
8 introduction
9 tutorial
10 simulations
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new version released,in silico,in vitro,nicholas,navin,wigler lab,navin@cshl edu,introduction,tutorial,simulations,applications,download,links,publications,people
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PROBER.CSHL.EDU | prober.cshl.edu Reviews

https://prober.cshl.edu

PROBER is an oligonucleotide primer design software application that can generate highly specific probes for use in fluorescence in-situ hybridization ( FISH. And other in-situ labeling methods by densely tiling relatively small genomic intervals. Prober was written in C# 2005 and has sub-programs that are complied as executables that were written in c, perl and splus. When running PROBER you will need to have the .net framework 2.0. Installed on your pc machine. Cold Spring Harbor Laboratory.

INTERNAL PAGES

prober.cshl.edu prober.cshl.edu
1

PROBER.CSHL.EDU

http://prober.cshl.edu/about.html

My name is Nicholas Navin and I am a programmer / Ph.D. student in Mike Wigler's lab at the Cold Spring Harbor Laboratory. PROBER was written in Mike Wigler's lab at the Cold Spring Harbor Laboratory. This software was orginally designed to determine the copy number of amplifications and deletions that occur in cancer cells. However, many other laboratries are now using. To determine genomic copy number in autism and other gen.

2

PROBER.CSHL.EDU

http://prober.cshl.edu/journals.html

Paper, if you are using PROBER for research :. Navin N, Grubor V, Hicks J, Leibu E, Thomas E, Troge J, Riggs M, Lundin P, Maner S, Sebat J, Zetterberg A, Wigler M. PROBER : oligonucleotide FISH probe design software. Bioinformatics. 2006 Jun 1. Epub. Thomas EE, Srebro N, Sebat J, Navin N, Healy J, Mishra B, Wigler M. Distribution of short paired duplications in mammalian genomes. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10349-54. Epub 2004 Jul 6. PMID: 15240876.

3

PROBER.CSHL.EDU

http://prober.cshl.edu/simulations.html

Avoiding Repetitive DNA Elements. In order to test the ability of the genomic block algorithm in avoiding repetitive DNA elements that occur in the human genome, a series of simulations were conducted using inserted LINEs and LTRs. A highly unique 100kb genomic sequence was obtained from the human genome (chr7:28,300,000-28,400,000bp). As a control sequence, to which LINEs and LTRs were inserted at regular intervals. Control Sequence from UCSC HG17 chr7:28,300,000-28,400,000bp. With very low repeats.

4

PROBER.CSHL.EDU

http://prober.cshl.edu/tutorial.html

Section 1 - DAS.DNA. Section 2 - MerMatch. Section 3 - Tolerance. Section 4 - PROBER. Section 5 - Output. After downloading the *.zip Prober installer file from the 'downloads' section, unzip it into a temporary directory with full directory expansion. If you are using WINZIP then open the zip file, press the extract button and check the ' use folder names. If it is not installed into this directory, then you will be unable to run 'MerMatch' or 'Tolerance'. Chromosome 11 : 1,000,000 - 1,100,000 bp.

5

PROBER.CSHL.EDU

http://prober.cshl.edu/index.html

PROBER is an oligonucleotide primer design software application that can generate highly specific probes for use in fluorescence in-situ hybridization ( FISH. And other in-situ labeling methods by densely tiling relatively small genomic intervals. Prober was written in C# 2005 and has sub-programs that are complied as executables that were written in c, perl and splus. When running PROBER you will need to have the .net framework 2.0. Installed on your pc machine. Cold Spring Harbor Laboratory.

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PROBER.CSHL.EDU

PROBER is an oligonucleotide primer design software application that can generate highly specific probes for use in fluorescence in-situ hybridization ( FISH. And other in-situ labeling methods by densely tiling relatively small genomic intervals. Prober was written in C# 2005 and has sub-programs that are complied as executables that were written in c, perl and splus. When running PROBER you will need to have the .net framework 2.0. Installed on your pc machine. Cold Spring Harbor Laboratory.

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