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R&D Returns | Strategy, Transformation, and Value Realization for R&DCritiquiing what has worked, plus new ideas that are creating value now for Life Science & BioPharma fimrs.
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Critiquiing what has worked, plus new ideas that are creating value now for Life Science & BioPharma fimrs.
http://www.randdreturns.com/
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Terrence McCormick
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View this contact
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R&D Returns | Strategy, Transformation, and Value Realization for R&D | randdreturns.com Reviews
https://randdreturns.com
Critiquiing what has worked, plus new ideas that are creating value now for Life Science & BioPharma fimrs.
randdreturns.com
Financial | R&D Returns
http://www.randdreturns.com/category/financial
8220;The Best Drug Companies Of The Past 15 Years? February 14, 2012. Matt Herper in Forbes’ “the Medicine Show” posts a point of view by Bernard Munos on what firms have done best in terms of approved drugs since 1995. The link is here (http:/ onforb.es/zb6xgu), as are my comments on this provocative topic. … Continue reading →. New Medical Entities /$ Increasing! June 29, 2011. Continued laments on R&D performance. February 12, 2011. McKinsey article hits close to home…. January 15, 2011. While I have ...
“Big BioPharma” Converts | R&D Returns
http://www.randdreturns.com/converts-to-big-biopharma
8220;Big BioPharma” Converts. The prospects, practice and perception of biotech therapies has dramatically evolved in the past decade. Presently, the biggest Pharma’s all have major biotech divisions, or altered their core business model towards biotech (vs. the synthetic chemistry approach.). But only seven to eight years ago, there was little talk of regulatory biosimilars . Note that for drugs subject to generic entry, the drop-off is substantial. The right hand graph reflects average sales of biotech...
“The Truly Staggering Cost Of Inventing New Drugs” | R&D Returns
http://www.randdreturns.com/the-truly-staggering-cost-of-inventing-new-drugs
8220;The Best Drug Companies Of The Past 15 Years? Decentralized R&D the “winning strategy”? 8211; Apple begs to differ →. 8220;The Truly Staggering Cost Of Inventing New Drugs”. February 14, 2012. Another provocative piece in Forbes. That implies the cost of developing a new drug could be as high as $12B! This approach has a number of flaws (as does: “ Best Drug Companies. 8220;) All produce (provoke? Dollars and it can be misleading to represent it as the key metric. So, there are plenty of statistics ...
A History of “time to market” thinking in Pharma | R&D Returns
http://www.randdreturns.com/a-history-of-time-to-market-thinking-in-pharma
A History of “time to market” thinking in Pharma. For those looking for the core ideas vs. a narrative, page down to the BOTTOM LINE ). Some assumptions were needed to estimate the extra sales we would reap ahead of generic competition, but the calculations of the net present value were straightforward. However the response from the financial directors evaluating projects was a shock. We were told. Acceleration just cannot have this large an impact go back and recalculate. The resulting dialog was even m...
Grasping the Information Explosion to Advantage | R&D Returns
http://www.randdreturns.com/grasping-the-information-explosion-to-advantage
Grasping the Information Explosion to Advantage. Firms increasingly recognize that better, faster use of their information is the key to success. This is even more important to Life Science firms as they address an explosion of data. Their big bang occurred in the past decade, creating new fields like proteomics, metabolonomics, disease modeling, etc., and their new data types. It cannot be stressed enough that this diversity is even more challenging than just an increase in the volume of data. Let’s con...
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biotechtranslated | Some thoughts from a scientist who moved to the business side of biotech | Page 2
https://biotechtranslated.com/page/2
Some thoughts from a scientist who moved to the business side of biotech. Vivus’ new obesity drug: Will it get scooped by generics before it even hits the market? July 2, 2012. This past Wednesday, the FDA approved. So Arena looks like they have a real winner on their hands. The next obesity drug up for approval is Qnexa from Vivus. I’ve written about Qnexa in the past ( here. The clinical trial data for Qnexa is actually much more positive than that for Belviq. Almost 50% of patients taking Belviq.
Strategy | biotechtranslated
https://biotechtranslated.com/category/strategy
Some thoughts from a scientist who moved to the business side of biotech. How the government makes healthcare more expensive by cutting costs. January 3, 2014. Increasing healthcare costs are one of the most important issues facing the United States today. Although the rate of increase has slowed down. Over the past few years, the amount of money spent on healthcare in the US has risen at an alarming rate. Lets focus on the treatment of cancer for a moment; the cause and effect should be clear. To reduce...
The hygiene hypothesis goes on trial… | biotechtranslated
https://biotechtranslated.com/2011/07/30/the-hygiene-hypothesis-goes-on-trial
Some thoughts from a scientist who moved to the business side of biotech. Larr; A perfect example of regulatory risk…. It’s like watching 5 year olds play soccer. The hygiene hypothesis goes on trial…. July 30, 2011. If there is one thing that excites me about the biotech industry, it’s the possibility that everything that we think we know about how to treat a disease will get turned on its head. A great example of this is the Nobel Prize winning work by Barry Marshall and Robin Warren. On the role of.
Big pharma’s “pay-to-delay” deals: Helping or hurting patients? | biotechtranslated
https://biotechtranslated.com/2013/02/04/big-pharmas-pay-to-delay-deals
Some thoughts from a scientist who moved to the business side of biotech. Larr; A setback for the hygiene hypothesis. Just how much profit is there in a new drug? Big pharma’s “pay-to-delay” deals: Helping or hurting patients? February 4, 2013. A few weeks ago it was announced. Banning the deals and the Supreme Court will soon decide if the deals are legal. You might be wondering what these “pay-to-delay” deals are exactly, so lets look at a hypothetical example:. Where thing get complicated is that gene...
Science | biotechtranslated
https://biotechtranslated.com/category/science
Some thoughts from a scientist who moved to the business side of biotech. FDA dismisses study that shows generic drugs are lower quality than branded version. April 10, 2014. In this blog post I’m going to take a step away from the business side of the pharmaceutical industry and dive a little bit deeper in to the science. In March of last year, a paper. Paywall) and a poster. This is a important issue in the industry right now as several foreign generic manufacturers, such as Ranbaxy. Happens slowly....
General industry topics | biotechtranslated
https://biotechtranslated.com/category/general-industry-topics
Some thoughts from a scientist who moved to the business side of biotech. If we reduce wastage, drug prices won’t go down. May 30, 2016. Back in March, the NY Times. Published an article claiming that we lose $3 billion dollars each year because of the cancer drug that are wasted. The article was inspired by a paper. Going even further than that, Peter Bach, one of the authors of the paper, infers that drug companies are intentionally. Doing this to boost their profits! That’s quite an accusation. In rea...
October | 2013 | biotechtranslated
https://biotechtranslated.com/2013/10
Some thoughts from a scientist who moved to the business side of biotech. A setback for the hygiene hypothesis. October 29, 2013. It’s always interesting when a clinical trial you’ve been watching reads out. One of the first posts. I wrote for this blog was about a clinical trial that Coronado Biosciences was running based on the hygiene hypothesis. The company was testing the efficacy of. Ova (pig whipworm eggs) in treating Crohn’s disease. Well, Coronado Biosciences just released. Ova in several other ...
Mike Hamilton | biotechtranslated
https://biotechtranslated.com/author/biotechtranslated
Some thoughts from a scientist who moved to the business side of biotech. If we reduce wastage, drug prices won’t go down. May 30, 2016. Back in March, the NY Times. Published an article claiming that we lose $3 billion dollars each year because of the cancer drug that are wasted. The article was inspired by a paper. Going even further than that, Peter Bach, one of the authors of the paper, infers that drug companies are intentionally. Doing this to boost their profits! That’s quite an accusation. In rea...
clinicaltrialist.wordpress.com
(Don’t) Blame the Chemists | clinicaltrialist
https://clinicaltrialist.wordpress.com/productivity/dont-blame-the-chemists
Why Clinical Trials Fail. Whence the Low Productivity? Don’t) Blame the Chemists. Castalia, Kinetics, Space. Small Sample Size Paradox. Terra Incognita of Science. What’s in a Name? Don’t) Blame the Chemists. Couple of days ago, I was talking to a medicinal chemist about why drug development productivity might have decreased. I pushed him to explain and here is what he said. 1) good chemists can get you good compounds against any target. But is that the way it should be? Are they doing their job if they ...
clinicaltrialist.wordpress.com
Productivity | clinicaltrialist
https://clinicaltrialist.wordpress.com/productivity
Why Clinical Trials Fail. Whence the Low Productivity? Don’t) Blame the Chemists. Castalia, Kinetics, Space. Small Sample Size Paradox. Terra Incognita of Science. What’s in a Name? This section contains pages on drug development productivity. Whence the Low Productivity? Don’t) Blame the Chemists. Castalia, Kinetics, and Space. Leave a Reply Cancel reply. Enter your comment here. Fill in your details below or click an icon to log in:. Address never made public). Notify me of new comments via email.
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R&D Returns | Strategy, Transformation, and Value Realization for R&D
R&D performance varies widely…. Fewer novel therapies seem to be coming from the drug industry as a whole. What is not generally recognized is how much firms differ in performance and (perhaps) why. This Lehman analysis. On where those “value levers” are. Key Advances in R&D Returns:. Automating Serendipity in Pharma R&D. Some lessons and principles. Precursors to “Six-Sigma” re-engineering. Why (and how) it took 10-15 years for BioPharma to find its way…. The time value of launch. 8220;One day sooner is...
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