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Sam Zeitlin

Left: A human cancer cell in mitosis. DNA in blue (DAPI), microtubules in green, and centromeres in red (CENP-A). Right: an immature neuron grown from an established human embryonic stem cell line in vitro. TUJ1 (beta III tubulin) in green, DNA in blue (DAPI), and CD44 in red. Follow me on Twitter.

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Sam Zeitlin | samzeitlin.com Reviews
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Left: A human cancer cell in mitosis. DNA in blue (DAPI), microtubules in green, and centromeres in red (CENP-A). Right: an immature neuron grown from an established human embryonic stem cell line in vitro. TUJ1 (beta III tubulin) in green, DNA in blue (DAPI), and CD44 in red. Follow me on Twitter.
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Sam Zeitlin | samzeitlin.com Reviews

https://samzeitlin.com

Left: A human cancer cell in mitosis. DNA in blue (DAPI), microtubules in green, and centromeres in red (CENP-A). Right: an immature neuron grown from an established human embryonic stem cell line in vitro. TUJ1 (beta III tubulin) in green, DNA in blue (DAPI), and CD44 in red. Follow me on Twitter.

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Sam Zeitlin Publications

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What was I doing? CENP-A Ser7 is phosphorylated during mitosis (JCS 2001). Double-strand DNA breaks rapidly recruit CENP-A in human and mouse cells (PNAS, 2009). Human UNG2 is both necessary and sufficient for CENP-A assembly. PLoS ONE, 2011). Xenopus CENP-A assembly requires uracil generation and UNG2. DNA Repair, 2005).

3

Friendly faces: People I admire

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Location

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Jean Wang’s lab at the Moores-UCSD Cancer Center. John Newport’s Lab in the UCSD Department of Biology. Sam did her thesis work with Kevin Sullivan at. Kevin is now at. Of Ireland (NUI) at Galway. Don Cleveland’s Lab at the Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine at UCSD. Michael Berns’ Lab in the Department of Bioengineering at UCSD.

5

Not all DNA damage is bad

http://samzeitlin.com/Not%20all%20DNA%20damage%20is%20bad.html

What doesn’t kill you, you might have done to yourself. Not all DNA damage is bad. Yes, gamma-rays and ultraviolet light can kill you, but they can also be therapeutic when applied to the right places at the right doses. Some chemotherapeutics kill cancer cells by inducing DNA damage, which is bad for the cancer, but good for you! Even DNA damage can make you stronger.

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Sam Zeitlin

Left: A human cancer cell in mitosis. DNA in blue (DAPI), microtubules in green, and centromeres in red (CENP-A). Right: an immature neuron grown from an established human embryonic stem cell line in vitro. TUJ1 (beta III tubulin) in green, DNA in blue (DAPI), and CD44 in red. Follow me on Twitter.

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