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Douglas Theobald's Lab

Theobald Lab web page

http://theobald.brandeis.edu/

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Douglas Theobald's Lab | theobald.brandeis.edu Reviews
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Theobald Lab web page
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2 evolution
3 lysozyme
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5 telomere
6 superpositioning
7 TEBP
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9 ancestral
10 protein resurrection
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Douglas Theobald's Lab | theobald.brandeis.edu Reviews

https://theobald.brandeis.edu

Theobald Lab web page

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1

Theobald Lab:People

http://theobald.brandeis.edu/people.html

Waltham, MA 02453. Douglas L. Theobald. Waltham, MA 02454. The lab, with the lovely historic Brandeis Usen Castle in background, August 2, 2013. Left to right: Rick Roy, Erin Devine, Brian Beckett, Joe Jacobowitz, Kristine Mackin, Jeff Boucher, Phil Steindel, Douglas Theobald. Brian C. Beckett. Rick works on understanding the functional and structural constraints on universally conserved residues in Type I rhodopsins. Erin Devine, PhD. Michelle Y. Fry (2015). Kristine Mackin, PhD. Kristine's thesis proje...

2

Theobald Lab: Publications

http://theobald.brandeis.edu/publications.html

Waltham, MA 02453. Theobald lab publications at PubMed. Erin L. Devine, Douglas L. Theobald, and Daniel D. Oprian (2016). Relocating the active-site lysine in rhodopsin: 2. Evolutionary intermediates.". Doi:10.1021/acs.biochem.6b00478. Phillip A. Steindel, Emily H. Chen, Jacob D. Wirth, and Douglas L. Theobald (2016). Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases.". 25(7):1319-1331. [ Open Access. Douglas L. Theobald (2016). Kristine A. Mack...

3

Theobald Lab: QCP Method

http://theobald.brandeis.edu/qcp

The QCP Superposition Method. Waltham, MA 02453. The Quaternion Characteristic Polynomial method: Ultrafast determination of the minimum RMSD and the optimal least-squares rotation matrix. Method avoids the costly matrix decomposition by taking advantage of special properties of the quaternion representation of rotations and of the characteristic polynomial of the 4×4 "key" matrix. If the optimal rotation matrix is also desired, then the best rotation is given by the corresponding eigenvector, which we c...

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Alternating Access: June 2011

http://alternatingaccess.blogspot.com/2011_06_01_archive.html

Tuesday, June 28, 2011. During the course of this project, I've written quite a bit of code in order to run simulations and analyze the data produced during those simulations. I strongly believe that it is in the interest of the scientific community to make as much of the code that we write and use open source. Both for purposes of transparency and reproducibility, but also to allow others to benefit from the effort in their own research. I have benefited greatly from open source projects like OpenMM.

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Alternating Access: Open Source Software

http://alternatingaccess.blogspot.com/2011/06/open-source-software.html

Tuesday, June 28, 2011. During the course of this project, I've written quite a bit of code in order to run simulations and analyze the data produced during those simulations. I strongly believe that it is in the interest of the scientific community to make as much of the code that we write and use open source. Both for purposes of transparency and reproducibility, but also to allow others to benefit from the effort in their own research. I have benefited greatly from open source projects like OpenMM.

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Infomation Wizards And Components. Monday, October 18, 2010. Enjoy it: lots to talk about topics for undying domain. Domain topic, it seems always lots to talk about the same. One is a famous name to be robbed of enterprises registered, a company will be a high price to buy back their own company domain name, this is the so-called "Gold has a price, the domain name is priceless," Because of this, only for those opportunities to make money a lot of domain investors. Bus Manufacturing Co., Ltd. Tia...In th...

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theobald.brandeis.edu theobald.brandeis.edu

Douglas Theobald's Lab

Waltham, MA 02453. Evolution of macromolecular structure, mechanism, dynamics, and function. Crystals and 2.8 Å diffraction of a resurrected ancestral enzyme, malate dehydrogenase from green sulfur bacteria (Chlorobia). Our lab is interested in many diverse, basic, and unresolved problems in molecular evolution:. What are the mechanisms by which new functions evolve? What are the physical constraints on protein evolution? How do substitutions distal from the active site affect catalytic activity? The ans...

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Herzlich Willkommen auf unserer Internetseite! Wir sind Ihr kompetenter Partner im Bereich Heizung, alternative Energien, Sanitär und Bad sowie Elektro. Auf rund 500m sind ca. 20 Bäder, eine Verkaufsstelle für Heizungs- und Sanitärmaterial, sowie eine Ausstellung für Heizkessel und alternative Energien eingerichtet. Unser Unternehmen wurde 1976 von Herrn Alfred Theobald gegründet und 1995 in eine GmbH umgewandelt. Unser Stammsitz befindet sich in Kusel. Ausstellung Verkauf: Glanstrasse 52 66869 Kusel.

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