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Arog Pharmaceuticals, Inc. 5420 LBJ Freeway,. Dallas, TX 75240.

http://www.arogpharma.com/

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Home | Arog Pharmaceuticals, Inc. | arogpharma.com Reviews
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Arog Pharmaceuticals, Inc. 5420 LBJ Freeway,. Dallas, TX 75240.
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KEYWORDS
1 about us
2 our mission
3 scientific advisory board
4 executive management
5 pipeline
6 crenolanib flt3
7 crenolanib pdgfr
8 clinical trials
9 intellectual property
10 indications
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about us,our mission,scientific advisory board,executive management,pipeline,crenolanib flt3,crenolanib pdgfr,clinical trials,intellectual property,indications,acute myeloid leukemia,gastrointestinal stromal tumor,lung cancer,glioma,press / publications
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Home | Arog Pharmaceuticals, Inc. | arogpharma.com Reviews

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Arog Pharmaceuticals, Inc. 5420 LBJ Freeway,. Dallas, TX 75240.

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News & Events | Arog Pharmaceuticals, Inc.

http://www.arogpharma.com/news-events

Arog Pharmaceuticals, Inc. Arog Pharmaceuticals Presents Crenolanib Clinical Data at 57th American Society of Hematology Annual Meeting. View Full Press Release. Arog Pharmaceuticals Announces Abstracts to be Presented at the 2015 American Society of Hematology Annual Meeting (ASH). December 7th, 2015. View Full Press Release. Arog Pharmaceuticals Appoints Dr. Ada Braun as Senior Vice President of Clinical Development. October 30, 2015. View Full Press Release. May 5, 2015. Arog Pharmaceuticals, Inc....

2

Our Mission | Arog Pharmaceuticals, Inc.

http://www.arogpharma.com/mission

Arog Pharmaceuticals, Inc. Arog Pharmaceuticals, Inc. has been formed to expedite and streamline the transition of early stage molecules into areas of unmet therapeutic needs. We are committed to scientifically validated drug development in collaboration with like-minded investigators and institutions. 5420 LBJ Freeway,. Dallas, TX 75240.

3

A UNIQUE, POTENT, & SELECTIVE PDGFR INHIBITOR | Arog Pharmaceuticals, Inc.

http://www.arogpharma.com/lung

Arog Pharmaceuticals, Inc. A UNIQUE, POTENT, and SELECTIVE PDGFR INHIBITOR. PLATELET DERIVED GROWTH FACTOR RECEPTOR α (PDGFRα) AMPLIFICATION and OVEREXPRESSION IN NON-SMALL CELLl LUNG CANCER (NSCLC). PDGFRα activation has been reported in up to 13% of NSCLC tumors, with squamous cell carcinoma (SCC) being the most common. PDGFR CN amplification 10: 8.7% of SCC. PDGFR CN amplification 4-10: 1.9% of SCC. Total PDGFR amplification in SCC: 10.6%. Amplification of PDGFR in Squamous Cell Carcinoma. VEGF mediat...

4

Gastrointestinal Stromal Tumor

http://www.arogpharma.com/indication_gist

Arog Pharmaceuticals, Inc. CRENOLANIB BESYLATE IN D824V GIST. PLATELET-DERIVED GROWTH FACTOR RECEPTOR-A, MUTATIONS IN GIST. Activating mutations in PDGFRA are seen in 8-10% of GIST. Is seen in 4-5% of GIST. Is intrinsically resistant to imatinib and sunitinib. CRENOLANIB INHIBITION OF D842V MUTATED PDGFRA. Crenolanib inhibits the phosphorylation of D842V mutated PDGRA at nanomolar concentrations in CHO cell lines. CRENOLANIB INHIBITS PHOSPHORYLATION OF D842V IN GLIAL CELLS. A patient showed a marked redu...

5

Glioma | Arog Pharmaceuticals, Inc.

http://www.arogpharma.com/glioma

Arog Pharmaceuticals, Inc. Every year, about 2,200 US children aged less than 20 years are diagnosed with a malignant brain tumor. Brain stem gliomas are the tumors originating in the stem of the brain and account for 10% to 15% percent of pediatric brain tumors. Most brain stem gliomas occur in the pons (hence pontine gliomas) and are highly aggressive and infiltrative. The peak incidence is between ages 5 and 10. Diffuse intrinsic pontine glioma (DIPG). Primary brain tumors are classified as either gli...

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Clients - Bioscience Valuation

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Through its 'Corporate Partnership Program', Bioscience Valuation has provided exceptional support in the tranformation of our business model. BSV's evidence-based assessments proved invaluable for our strategic decision making as well as for preparing our corporate transactions. ”. Peter Llewellyn-Davies, CFO/CBO. R&D Risk Analysis &. Corporate Finance / M&A. Healthcare / Life Science. Cell Technologies, s.l. Aesculap AG and Co. KG. AiCuris GmbH and Co. KG. Alternative Gene Expression S.L.

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