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ENIGMA-II Trial

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. A 5-year multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N2O) from the anaesthetic gas mixture in patients with coronary artery disease undergoing major surgery. Ndash; General anaesthesia and FiO. Ndash; General anaesthesia and FiO. The trial commenced enrolment in May 2007. 1 In patients undergoing anaesthesia for major surgery, avoidance of N.

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ENIGMA-II Trial | enigma2.org.au Reviews

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Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. A 5-year multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N2O) from the anaesthetic gas mixture in patients with coronary artery disease undergoing major surgery. Ndash; General anaesthesia and FiO. Ndash; General anaesthesia and FiO. The trial commenced enrolment in May 2007. 1 In patients undergoing anaesthesia for major surgery, avoidance of N.

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1 enigma ii

2 summary

3 trial staff

4 participating centres

5 analysis plan

6 links

7 trial status

8 completed

9 patients randomised

10 brief summary

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enigma ii,summary,trial staff,participating centres,analysis plan,links,trial status,completed,patients randomised,brief summary,group 1,group 2,main study hypothesis,funding,registration,sophie wallace

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ENIGMA-II Trial | enigma2.org.au Reviews

https://enigma2.org.au

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. A 5-year multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N2O) from the anaesthetic gas mixture in patients with coronary artery disease undergoing major surgery. Ndash; General anaesthesia and FiO. Ndash; General anaesthesia and FiO. The trial commenced enrolment in May 2007. 1 In patients undergoing anaesthesia for major surgery, avoidance of N.

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enigma2.org.au

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ENIGMA-II Trial

http://enigma2.org.au/analysis

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. Statistical Analysis Plan and Definition of Trial Endpoints (27th August, 2013). A composite of death and serious cardiovascular events (MI, stroke, cardiac arrest, or pulmonary embolism) measured at 30 days after surgery. Secondary Endpoints (within 30 days of surgery). Using the Universal definition: Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD; the Writing Group o...

2

ENIGMA-II Trial

http://enigma2.org.au/home

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. A 5-year multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N2O) from the anaesthetic gas mixture in patients with coronary artery disease undergoing major surgery. Ndash; General anaesthesia and FiO. Ndash; General anaesthesia and FiO. The trial commenced enrolment in May 2007. 1 In patients undergoing anaesthesia for major surgery, avoidance of N.

3

ENIGMA-II Trial

http://enigma2.org.au/summary

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. There are about 20 million anaesthetics given each year in the US (1:10 of the population), with the majority receiving N. O interferes with vitamin B12 and folate metabolism. This impairs production of methionine (from homocysteine), used to form tetrahydrofolate and thymidine during DNA synthesis. It has been repeatedly demonstrated that N. Our previous trial (ENIGMA) studied 2050 patie...

4

ENIGMA-II Trial

http://enigma2.org.au/centres

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. Alfred Hospital – Paul Myles. Royal Melbourne Hospital – Kate Leslie. St Vincent’s Hospital – Brendan Silbert. The Austin Hospital – Phillip Peyton. Royal Perth Hospital – Michael Paech. Monash Medical Centre – Rod McRae. Dandenong Hospital – Rick Bulach. Geelong Hospital – Steve Bolsin. Royal Prince Alfred Hospital – Tim McCulloch. Westmead Hospital – Richard Halliwell. University Hospit...

5

ENIGMA-II Trial

http://enigma2.org.au/staff

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. Prof Paul Myles, Director. Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Chair, Academic Board of Anaesthesia and Perioperative Medicine Monash University. Paul Myles (Chair), Kate Leslie, Phil Peyton, Mike Peach, Scott Beattie, PJ Devereaux, Dan Sessler, Andrew Forbes. Paul Myles, Kate Leslie, PJ Devereaux, Dan Sessler. Data Safety Monitoring Committee.

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lachgas-lehrbuch.de

Lachgas-Lehrbuch online

http://www.lachgas-lehrbuch.de//index.php

Lachgas-Lehrbuch » Start. Grundlagen · Informationen. Aktuelles · Neuigkeiten. Auch der 1-Jahres-Follow-Up der ENIGMA-II-Studie belegt die Sicherheit von Lachgas während Narkose. Die ersten Daten der ENIGMA-II-Studie hatten gezeigt, dass kardio-vaskulärer Ereignisse wie Myokardinfarkte oder Schlaganfälle nicht häufiger während Anästhesien mit 70% Lachgas auftreten. Auch auf das Langzeit-Outcome. Raquo; Leslie et al., Anesthesiology 2015. Und auch der Zahnmedizin. Wichtig genug, eine Task Force von Expert...

spacer.org.uk

Archival Projects – SPACeR

http://www.spacer.org.uk/projects/archival-projects

Quality Improvement Fellow Patient Safety and Simulation. Perioperative Medicine and Research. Clinical Fellow in Anaesthesia for Major Oncological Surgery. Medical Education and Senior Critical Care Fellow. Clinical Fellow in Clinical Simulation and Anaesthesia. Clinical Fellow in Perioperative Medicine and CPET. Clinical Fellow in Patient Safety and Quality Improvement. An international multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N. Published in the Lancet. Patient...

lachgas-lehrbuch.de

Lachgas-Nebenwirkungen-Kontraindikationen: Diffusionshypoxie - Übelkeit - Erbrechen - Vitamin B12 - Missbrauch/Drogen (Lachgas-Lehrbuch)

http://www.lachgas-lehrbuch.de/Nebenwirkungen/Lachgas-Nebenwirkungen.php

Seit der ersten klinischen Anwendung von Lachgas durch H. Wells 1844 haben Zehntausende Patienten Lachgas zur Narkose und Sedierung erhalten. Die hier beschriebenen Nebenwirkungen seit langem bekannt und die Beachtung sich daraus ergebender Indikationen und Kontraindikationen begründen die nun über 150 Jahre währende, weltweite sichere Anwendung von Lachgas. Schulte am Esch 2001. Sicherheit von Lachgas in der Anästhesie? Ersten Aufschluss gab die sog. 'ENIGMA'-Studie [Myles 2007]. Die ENIGMA-II-Studie, d...

lachgas-lehrbuch.de

Lachgas-Nebenwirkungen-Kontraindikationen: Diffusionshypoxie - Übelkeit - Erbrechen - Vitamin B12 - Missbrauch/Drogen (Lachgas-Lehrbuch)

http://www.lachgas-lehrbuch.de//Nebenwirkungen/Lachgas-Nebenwirkungen.php

Seit der ersten klinischen Anwendung von Lachgas durch H. Wells 1844 haben Zehntausende Patienten Lachgas zur Narkose und Sedierung erhalten. Die hier beschriebenen Nebenwirkungen seit langem bekannt und die Beachtung sich daraus ergebender Indikationen und Kontraindikationen begründen die nun über 150 Jahre währende, weltweite sichere Anwendung von Lachgas. Schulte am Esch 2001. Sicherheit von Lachgas in der Anästhesie? Ersten Aufschluss gab die sog. 'ENIGMA'-Studie [Myles 2007]. Die ENIGMA-II-Studie, d...

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enigma2.org.au

ENIGMA-II Trial

Nitrous oxide anaesthesia and cardiac morbidity after major surgery. A randomised controlled trial. Login to Web CRF. A 5-year multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N2O) from the anaesthetic gas mixture in patients with coronary artery disease undergoing major surgery. Ndash; General anaesthesia and FiO. Ndash; General anaesthesia and FiO. The trial commenced enrolment in May 2007. 1 In patients undergoing anaesthesia for major surgery, avoidance of N.

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