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Farmacokratia

HD pharmacology

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Farmacokratia | farmacokratia.blogspot.com Reviews
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Farmacokratia | farmacokratia.blogspot.com Reviews

https://farmacokratia.blogspot.com

HD pharmacology

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1

Farmacokratia: 2013.01

http://farmacokratia.blogspot.com/2013_01_01_archive.html

I found very interesting post. In Cross Validated website: Famous statistician quotes. I really liked some of them. All models are wrong, but some are useful. George E. P. Box. Statisticians, like artists, have the bad habit of falling in love with their models. George E. P. Box. In God we trust. All others must bring data. W. Edwards Deming. Statistical thinking will one day be as necessary a qualification for efficient citizenship as the ability to read and write. H.G. Wells. We are drowning in informa...

2

Farmacokratia: Famous statistician quotes

http://farmacokratia.blogspot.com/2013/01/famous-statistician-quotes.html

I found very interesting post. In Cross Validated website: Famous statistician quotes. I really liked some of them. All models are wrong, but some are useful. George E. P. Box. Statisticians, like artists, have the bad habit of falling in love with their models. George E. P. Box. In God we trust. All others must bring data. W. Edwards Deming. Statistical thinking will one day be as necessary a qualification for efficient citizenship as the ability to read and write. H.G. Wells. We are drowning in informa...

3

Farmacokratia: 2012.08

http://farmacokratia.blogspot.com/2012_08_01_archive.html

CADD success stories. Part2. Just back from the quit a long job searching, haven't read collection of TOCs for a 3 months. So, there a lot of CADD examples I want to share with you. 8 β-Amyloid Aggregation Inhibitors. Molecular dynamics (Markov state model molecular dynamics), shape-based virtual screening (ROCS by OpenEye). Structure-based drug design with mutant proteins (GOLD). 10 Human 5-Lipoxygenase inhibitors. Homology modeling, docking, molecular dynamics, virtual screening (DOCK, PSDOCK, AutoDock).

4

Farmacokratia: BioIT Eorld 2012 - day two

http://farmacokratia.blogspot.com/2012/04/bioit-eorld-2012-day-two.html

BioIT Eorld 2012 - day two. I think BioIT World. Is the biggest conference in the world that mix life science and informatics. All of the molecular modeling software developer monsters were presented here: ChemAxon, OpenEye, Accelrys. GGA software was a specific interest for me, first because molecular modeling software development team is located in Saint Petersburg, one of the most beautiful Russian cities, second - because of their open source initiative. IT Infrastructure – Hardware. Management and i...

5

Farmacokratia: A new era for drug discovery is already here: biologics vs small compound drugs

http://farmacokratia.blogspot.com/2012/12/a-new-era-for-drug-discovery-is-already.html

A new era for drug discovery is already here: biologics vs small compound drugs. I found a very interesting post in the Biotech-Now blog "Small Companies, Big Returns" - about the best performing biotech/pharmatech companies according to their revenue in 2012, who's market capitalization have jumped 100 percent. And what triggered me that half of the first 10 companies are working with either biologic or new drug delivery systems for the old or well studied drugs. Here is the Top 10. The next 10 companies.

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The plate is bad: January 2015

http://theplateisbad.blogspot.com/2015_01_01_archive.html

Thursday, January 29, 2015. Finding mass spectra with PostgreSQL: Tanimoto similarity in SQL. Now that we can store mass spectra in PostgreSQL, the next question is how to find them? There is more than one solution to this problem. One is the Tanimoto coefficient or Jaccard index. The Tanimoto coefficient T can be calculated as T = c / (a b-c). With c the number of peaks both spectra have in common and a and b the number of peaks in each spectrum. Expresses the distance between two spectra. Select (selec...

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: November 2014

http://theplateisbad.blogspot.com/2014_11_01_archive.html

Wednesday, November 26, 2014. A working RAMDisk for PostgreSQL on Windows. Aside from the debate if this is useful or dangerous, I tried several free RAMDisks for Windows, Gavotte RamDisk, AMD Radeon RAMDisk and SoftPerfect RAM Disk - and none of them works well with PostgreSQL. Either PostgreSQL refuses to use them at all for datafiles or it seems to work, but at some point in time the server tells you, that there is something wrong. With the datafiles on the ramdrive and data corruption bites.

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: September 2014

http://theplateisbad.blogspot.com/2014_09_01_archive.html

Wednesday, September 3, 2014. Using Code: Blocks with the Intel C/C compiler on Windows in five minutes. Code: Blocks apparently does not support the latest Intel C/C compiler out of the box. Trying to set up the necessary include paths for both the Visual Studio compiler and the Intel compiler leads to madness. But there is an easier way:. The 32 bit toolchain executables are prefixed ia32. The 64 bit ones intel64. Just start codeblocks.exe. And it works without further ado. Wednesday, September 03, 2014.

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: Row, row, row your boat...

http://theplateisbad.blogspot.com/2015/08/row-row-row-your-boat.html

Tuesday, August 4, 2015. Row, row, row your boat. Josh Berkus gave a hint that - and how - a similar functionality might be achieved with stock PostgreSQL. Let's see, if we can analyze a continuous twitter stream too. First, we need a fast table to act as the ringbuffer:. CREATE UNLOGGED TABLE tstest.tstream. Rec timestamp with time zone NOT NULL DEFAULT clock timestamp(),. Tevent jsonb NOT NULL,. CONSTRAINT pk tstream PRIMARY KEY (rec). Written in Java using the hosebird. Tuesday, August 04, 2015. The o...

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: February 2015

http://theplateisbad.blogspot.com/2015_02_01_archive.html

Thursday, February 26, 2015. The Long Tail - vertical table partitioning II. Having all parts from the previous post in place, some mechanism to do the routine maintenance by calling the transfer function automagically, is needed. Of course this could be done with pgAgent or it could be done with cron, but since it should be elegant, this calls for a background worker process. For illustration purposes, I wrote a sample implementation called worker ltt. To shared preload libraries. But it really works.

chupvl.com chupvl.com

Vladimir Chupakhin

http://www.chupvl.com/misc.html

Mining of Life Science Data. Sometimes I share ideas in my official blog. But some ideas fit only to my Russian blog. Unofficial and mostly non-scientific. I am also occasional twitter. I am also represented in more serious social networks: github. I really like biking and traveling preferably somewhere with mountains and wild nature or historically significant area. Currently learning how to fly, aka paragliding.

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: Deriving the elemental composition from a molformula in pgchem::tigress

http://theplateisbad.blogspot.com/2015/07/deriving-elemental-composition-from.html

Thursday, July 23, 2015. Deriving the elemental composition from a molformula in pgchem: tigress. Can generate molecular formulae like C3H6NO2-. But what if we need access to the elemental composition as a relation, e.g:. Fortunately, PostgreSQL is awesome:. CREATE OR REPLACE FUNCTION elemental composition(molformula TEXT). RETURNS TABLE(element TEXT, count INTEGER) AS. DECLARE token TEXT[];. DECLARE elements TEXT[];. Elements := ARRAY['C','N','O','P','S','Cl']; - expand as needed. Count := 1;. July 24, ...

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: October 2014

http://theplateisbad.blogspot.com/2014_10_01_archive.html

Thursday, October 30, 2014. ToroDB Adventures: Adding unimplemented commands. Ok" : 0, "errmsg" : "Unimplemented command: create", "code" : 1000002 }. Ok" : 1 }. In five simple steps:. 1) Find out how the command is called internally. toroDB tells you that in the message:. So it is "create". 2) Look up the "create" command. Start in QueryCommandProcessor.java. 3) "create" does nothing at the moment, so add some code. I just copied it from "createIndexes" so. 4) Now, ProcessorCaller. Class, make it known.

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: ToroDB up and running in five simple steps

http://theplateisbad.blogspot.com/2015/08/torodb-up-and-running-in-five-simple.html

Monday, August 17, 2015. ToroDB up and running in five simple steps. A working ToroDB installation in five steps. A working PostgreSQL instance, 9.4 or better:. Http:/ www.postgresql.org/download/. A suitable JRE, version 6 or higher. It has been mainly tested with Oracle JRE 8. The mongo shell and mongoimport from MongoDB:. Https:/ www.mongodb.org/. Some test data from citusdata:. Http:/ examples.citusdata.com/customer reviews nested 1998.json.gz. Hitman" Kevin MacLeod from incompetech.com.

theplateisbad.blogspot.com theplateisbad.blogspot.com

The plate is bad: nseq - A datatype for the efficient storage of nucleotide sequences in PostgreSQL

http://theplateisbad.blogspot.com/2015/06/nseq-datatype-for-efficient-storage-of.html

Thursday, June 25, 2015. Nseq - A datatype for the efficient storage of nucleotide sequences in PostgreSQL. Datatype allows to store DNA and RNA sequences consisting of the letters AGCT or AGCU respectively in PostgreSQL. By encoding four bases per Byte, it uses 75 percent less space on disk than text. While this idea is obvious and far from being novel, it still is one of the most efficient compression schemes for DNA/RNA, if not the most efficient. As of now, nseq. Enough said - here. BTW: If you need ...

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farmacokratia.blogspot.com farmacokratia.blogspot.com

Farmacokratia

It was a long time since I blog, but it was a very particular and important reason - I relocated to Spain, Toledo to work for Janssen R&D (pharmaceutical companies of Johnson&Johnson). The main research topic is chemogenomics. I prefer the term systems pharmacology, but it's often used interchangeably. PS: My blogging activity is a private matter and not connected with Janssen R&D. Links to this post. Sorry for overflew your RSS readers. Links to this post. I found very interesting post. A big computer, ...

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