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Protein Evolution (Rob Russell)Protein Evolution Heidelberg, Prof. Rob Russell
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Protein Evolution Heidelberg, Prof. Rob Russell
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Protein Evolution Heidelberg, Prof. Rob Russell
hub.russelllab.org
Protein Evolution (Rob Russell)
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A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. A landscape of the human cilium. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. Mechismo: Mechanistic interpretation of structural modifications. Deducing protein-protein interaction mechanism from siRNA screens. RhoA mutations in Burkitt's lymphoma. JAK3 mutations in porlymphocytic leukemia. Correlated mutaions in HIV Gag.
Group Members in Protein Evolution
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Protein-protein interactions, Modelling, Computational administration. Chemistry, Biochemistry, Biophysics and Molecular Biology in the lab. GTPases, Structure, Modifications. YingYing Jiang (PhD Student). Juan-Carlos Gonzales (PhD Student). Protein modifications and structure. Gurdeep Singh (MSc Student). Alumni of the Russell Group. 11/05/2016 Ciliary landscape data now available. 15/04/2015 New group member Juan-Carlos Gonzalez (PhD Student). 27/01/2015 New group member Gurdeep Singh (MSc Student).
Services offered by Protein Evolution
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This tool lets you interrogate data from our collaborative project on the Ciliary proteome, where we identified nearly 5000 interactions and over 50 complexes, involving more than 1000 proteins in the cilia. From Boldt, van Reeuwijk, Lu, Koutroumpas et al Nat Commun. From Betts et al, Nucl Acids Res. A database of protein-chemical interactions predicted by structure superimpositions: if you are interested in chemicals that might bind a particular protein or vice versa, then check it out. From Stark et al...
Protein Evolution (Rob Russell)
http://www.hub.russelllab.org/publications.shtml
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K*, van Reeuwijk J*, Lu Q. Koutroumpas K*, Nguyen TT, Texier Y, van Beersum SEC, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KLM, Arts HH, Betts MJ. Roepman R* Nat Commun. Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia. Lopez C, Bergmann AK, Paul U, Murga-Penas EM, Nagel I, Betts MJ. Schilhabel M, Schlesner M, S...
Protein Evolution (Rob Russell)
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Figure shows the effect knocking down components of proteins where mutations lead to 3M syndrome have on cilia in mpkCCD cells. We hypothesized that 3M Syndrome is a previously undescribed ciliary disease. Figure shows the effect of variants in patients suffereing sever ciliary diseases and how they affect specific sub-complexes and interaction within the intraflagellar transport complex B. Figure shows the architecture of the intraflagellar transport complex B deduced by our Socioaffinity metric. Figure...
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Protein Evolution (Rob Russell)
Cancer genetics meets mechanism. Cancer genetics meets mechanism. Cancer genetics meets mechanism. Genetic variants in cryptic choleostasis. Genetic variants in cryptic choleostasis. Genetic variants in cryptic choleostasis. Functional genetic variants in healthy genomes. Functional genetic variants in healthy genomes. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Cancer severity from interaction mechanisms. Protein ...
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