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Ken Garber, science writer | Expert reporting on biology and medicine

Dispatches from the Front Biological research today is a vast enterprise, with thousands of laboratories working to answer fundamental but sometimes obscure questions about living systems.   My stories are field notes from this mostly unremarked-on world, jottings that seek to shed a bit of light on some remarkable advances in our understanding of nature and…

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Ken Garber, science writer | Expert reporting on biology and medicine | kengarber.com Reviews

https://kengarber.com

Dispatches from the Front Biological research today is a vast enterprise, with thousands of laboratories working to answer fundamental but sometimes obscure questions about living systems.   My stories are field notes from this mostly unremarked-on world, jottings that seek to shed a bit of light on some remarkable advances in our understanding of nature and…

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April | 2014 | Ken Garber, science writer

https://kengarber.com/2014/04

Ken Garber, science writer. Expert reporting on biology and medicine. All posts for the month April, 2014. PARP Inhibitors Bounce Back (Nature Reviews Drug Discovery). A series of setbacks almost caused the demise of PARP inhibitors, but four companies are now beginning pivotal trials of these agents in breast and ovarian cancer. Nature Reviews Drug Discovery. A case of whiplash. Two recent developments have rehabilitated PARP inhibitors. First, independent investigators confirmed that iniparib and i...

2

January | 2015 | Ken Garber, science writer

https://kengarber.com/2015/01

Ken Garber, science writer. Expert reporting on biology and medicine. All posts for the month January, 2015. Between Disease and a Dish (Nature Biotechnology). Neuron- and glia-like cells derived from induced pluripotent stem cells promise tractable, individualized human models of Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis. Ken Garber explores the considerable challenges of recreating such diseases in the lab. Nature Biotechnology, August 2014. Plumbing a mysterious ALS mutation. These ex...

3

July | 2013 | Ken Garber, science writer

https://kengarber.com/2013/07

Ken Garber, science writer. Expert reporting on biology and medicine. All posts for the month July, 2013. Inducing Translation (Nature Biotechnology). The field of induced pluripotent stem cells is barely seven years old, but already three groups are close to launching clinical trials. Ken Garber looks into the prospects and perils. The extent to which epigenetic memory is an issue remains controversial. For example, Alex Meissner, a stem cell biologist at the Broad Institute of MIT and Harvard in Ca...

4

Potential Alzheimer’s Drug Spurs Protein Recycling (Science) | Ken Garber, science writer

https://kengarber.com/2014/06/09/potential-alzheimers-drug-spurs-protein-recycling

Ken Garber, science writer. Expert reporting on biology and medicine. Potential Alzheimer’s Drug Spurs Protein Recycling (Science). Science, April 25, 2014. In 2004, veteran structural biologists Gregory Petsko and Dagmar Ringe were looking for a way to make an impact on Alzheimer’s disease. Frustration ensued. We couldn’t see a fresh approach, Petsko says. You have APP residing for too long in the endosome, Small says. And so bam that’s where the enzymes start cleaving. The compound’s success also depen...

5

January | 2012 | Ken Garber, science writer

https://kengarber.com/2012/01

Ken Garber, science writer. Expert reporting on biology and medicine. All posts for the month January, 2012. Hepatitis C: Move Over Interferon (Nature Biotechnology). Nature Biotechnology, November 2011. Following approval of hepatitis C virus protease inhibitors Incivek and Victrelis, companies are partnering to devise all-oral combination antiviral regimens without interferon. A But the virus is a long way from vanquished. Ken Garber investigates. Given that roughly 170 million people worldwide are inf...

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