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Kina Search | | kinaseresearch.com Reviews
https://kinaseresearch.com
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Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Tarceva: running in place?
http://xcovery.blogspot.com/2007/01/tarceva-running-in-place.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Tarceva: running in place? One other note from the DNA earnings numbers: Tarceva sales grew 27% year over year and 7% sequentially (total: $107M). Very bad news for OSI. DNA is more motivated to push Avastin for solid tumors, so Tarceva is probably undermarketed by something between $500M and $1B. Subscribe to: Post Comments (Atom). Kinase Industry Biz News. Guide to biotech IP. IHOP - great protein db.
Useful links | MAP Kinase Resource
http://www.mapkinases.eu/useful-links
MAP kinases - a kinase family. MAP kinase family members have been found to regulate diverse biological functions by phosphorylation of specific target molecules (such as transcription factors, other kinases, etc.) found in cell membrane, cytoplasm and nucleus, and thereby participate in the regulation of a variety of cellular processes including cell proliferation, differentiation, apoptosis and imuno responses. (Marshall, 1994; Seger and Krebs, 1995);. MAP kinase service provider. UniGene is an experim...
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: A couple of extra thoughts from 2006
http://xcovery.blogspot.com/2007/02/couple-of-extra-thoughts-from-2006.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Thursday, February 22, 2007. A couple of extra thoughts from 2006. Anybody else surprised that Iressa racked up nearly a quarter billion in revenue? I thought AZ was just maintaining Iressa in the hopes that biomarker/personalized medicine research would fully characterize responders with significant sales to come only after conclusive studies, but Iressa is still achieving good levels of revenue. And actual sales (? Welcome to ou...
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Why drugs fall short in late-stage trials
http://xcovery.blogspot.com/2007/01/why-drugs-fall-short-in-late-stage.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Why drugs fall short in late-stage trials. Kick-ass article from McKinsey reviewing why drugs fail in P3, based on 650 small molecule trials since 1990. Over all diseases, 42% of leads failed P3, slightly worse than most models anticipate. (The Milken Model. Anticipates a 33% failure rate at this stage for small molecules.). Quantitative endpoints (biomarkers) improve the likelihood of P3 success.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Sutent now a first line therapy for RCC in Europe
http://xcovery.blogspot.com/2007/01/sutent-now-first-line-therapy-for-rcc.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Thursday, January 18, 2007. Sutent now a first line therapy for RCC in Europe. I found some information about SUTENT. Subscribe to: Post Comments (Atom). Kinase Industry Biz News. Guide to biotech IP. IHOP - great protein db. Seeking Alpha - solid biotech investment insight. Decent but dated summary of kinase therapeutics. Org Prep Daily (home of Milkshake). Whistling in the Wind. Kinase efforts you may not know of.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Way cool kinase target popularity charts
http://xcovery.blogspot.com/2007/01/way-cool-kinase-target-popularity.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Way cool kinase target popularity charts. The Kinase Research Portal. Has a cool application (linked in the header to this post) that shows kinase publication history and allows you to see target-specific publication trend graphs. Here's an example showing p38 publication trends (with a surprisingly steep upward trajectory.). Subscribe to: Post Comments (Atom). Kinase Industry Biz News.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Top 100 2006 Publications
http://xcovery.blogspot.com/2007/01/top-100-2006-publications.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Top 100 2006 Publications. The Kinase Research Portal. Has compiled what they consider the 100 best/most popular articles of the last year. The list (via the linked header for this post) is could be used as means of taking the pulse of kinase research. Gene target interest is very broad. I counted at least 25 different gene targets as article themes. Subscribe to: Post Comments (Atom). Interesting stor...
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: 2006 kinase drug performance
http://xcovery.blogspot.com/2007/02/2006-kinase-drug-performance.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, February 21, 2007. 2006 kinase drug performance. With the release of OSI's 4Q and year-end. Financial statements, the sales results for all 12 kinase-targeting drugs are finally available for the year 2006. And what a year it was. All told, we might see KDs contributing nearing $15B in annual sales in '07, with greater growth still to come. Nice table - thanks. Subscribe to: Post Comments (Atom). Kinase Industry Biz News.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Miscellany
http://xcovery.blogspot.com/2007/02/miscellany.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Saturday, February 03, 2007. With an assist from In the Pipeline. Thinks BMS and Sanofi shouldn't pair up. I'm really surprised that more people haven't looked at the historical performance of pharma M and A - it's overwhelmingly not pretty. Somewhat related, Forbes. Subscribe to: Post Comments (Atom). Kinase Industry Biz News. Guide to biotech IP. IHOP - great protein db. Seeking Alpha - solid biotech investment insight.
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KinasePhos
Is to computationally predict phosphorylation sites within given protein sequences. The known phosphorylation sites are categorized by substrate sequences and their corresponding protein kinase classes. Profile Hidden Markov Model (HMM). HD Huang*, T.Y. Lee, S.W. Tseng, and J.T. Horng. (2005) "KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites" Nucleic Acids Research, Vol. 33, W226-229. [PubMed]. CP1BB HUMAN, Platelet glycoprotein Ib beta chain [Precursor]. Bid Lab, Inst...
KinasePhos 2.0
Version of kinase-specific phosphorylation site prediction tool that is based the sequenece-based amino acid coupling-pattern analysis and solvent accessibility as new features of SVM (support vector machine). Paste a single sequence or several sequences in FASTA. Format into the field below:. Submit a file ( 2MB) in FASTA. Format directly from your local disk:. G protein-coupled receptor kinase(GRK). I kappa B kinase(IKK). Cell division cycle protein kinase(CDC2). G protein-coupled receptor kinase(GRK).
KinasePro
Kinase Chemistry – Just a year and a half behind the times. Monday Night Off Topic. An error has occurred; the feed is probably down. Try again later. On January 2, 2010. Posted in General Interest. On September 1, 2009. As always, being 18 months behind the times put you 6 months ahead of the curve. On August 13, 2009. Well maybe this compound will kill it: Polymorphic Forms / WO/2009/098612. Its from Pfizer no less –. Part Axitinib, part Birb, Part SGX… All MW: 700. Thanks for the email PN. In August 2...
Kinasera.com
Tel 372 5331 1111. Offers to biotech and pharmaceutical companies and academic laboratories novel tools for research targeted to protein kinases and their inhibitors. ARC-Photo differs from most of other available protein kinase inhibitor screening technologies as it measures the binding of the inhibitor to the kinase instead of determination of the retarding effect of the inhibitor on phosphorylation reaction. That makes the assay simpler, quicker, and cheaper. 2016 aastal toetab Euroopa Liidu Regionaal...
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Digital Journal – A research and expository notebook by Orest Kinasevych
A research and expository notebook by Orest Kinasevych. Mander (1991). Fantasy And Reality. (In the absence of the sacred.). March 31, 2018. 8220;Living constantly inside an environment of our own invention, reacting solely to things we ourselves have created, we are essentially living inside our own minds . Where evolution was once an interactive process between human beings and a natural, unmediated world, evolution is now an interaction between human beings and our own artifacts.” (p 32). March 21, 20...
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Kinasewich Benefits Consulting - Group Employee Benefits, Edmonton, Comox
Welcome to Kinasewich Benefits Consulting Ltd. (KBC). KBC is all that you’d expect from your insurance provider, and more. Our portfolio of risk management products include medical and dental insurance, extended health care options, travel insurance, disability insurance, accidental death and life insurance, as well as key man insurance, and group retirement plans. If you have a risk concern, we have a solution. Get an online quote.
Closet of whatnots | Photos. Ramblings. Whatnot…
Photos. Ramblings. Whatnot…. Fields of green in Co. Cork. December 8, 2013. I was off work recently for a bit more than a week and I spent part of that time going back through photos taken this year. as part of that I came across these pictures from a long weekend that we spent at Ballymaloe in Co. Cork. Onward to the photo! Horses at the RDS. August 19, 2013. July 11, 2013. And a couple of floating flowers:. Three months in, things that I miss. April 8, 2013. The first chunk is food related:. 7 Watching...
