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MK4MDD

Multi-level Knowledge base for Major Depressive Disorder (MK4MDD). Is an innovative informatics tool to integrate different levels of data in published MDD experimental studies and show the dynamic interplay of components in pathophysiological cascade of MDD. MK4MDD has three notable features:. An example on how to explore MK4MDD. A tutorial for database usage. BDNF, Dopamine, Amygdala or directly search to get all components at different level. Protein and other molecule. Cell and molecular pathway.

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Multi-level Knowledge base for Major Depressive Disorder (MK4MDD). Is an innovative informatics tool to integrate different levels of data in published MDD experimental studies and show the dynamic interplay of components in pathophysiological cascade of MDD. MK4MDD has three notable features:. An example on how to explore MK4MDD. A tutorial for database usage. BDNF, Dopamine, Amygdala or directly search to get all components at different level. Protein and other molecule. Cell and molecular pathway.
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2 advanced search
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MK4MDD | mdd.psych.ac.cn Reviews

https://mdd.psych.ac.cn

Multi-level Knowledge base for Major Depressive Disorder (MK4MDD). Is an innovative informatics tool to integrate different levels of data in published MDD experimental studies and show the dynamic interplay of components in pathophysiological cascade of MDD. MK4MDD has three notable features:. An example on how to explore MK4MDD. A tutorial for database usage. BDNF, Dopamine, Amygdala or directly search to get all components at different level. Protein and other molecule. Cell and molecular pathway.

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1

MK4MDD

http://mdd.psych.ac.cn/about.do

GSEA4GWAS (2010) and ICSNPathway (2011). The developers of MK4MDD have different education/research backgrounds, including molecular biology, medicine, neurobiology, computing science and bioinformatics. We have several collaborators working on MDD, including domestic and abroad. If you have any questions while using the site, please feel free to Contact Us. Institute of Psychology, CAS. Bioinformatics Lab, Institute of Psychology, CAS. Last update: October 10, 2015.

2

MK4MDD

http://mdd.psych.ac.cn/example.do

An example on how to explore MK4MDD. Currently, the molecular mechanism of MDD, especially how effect proteins play roles in MDD, is still unclear. To further investigate this, we can navigate the database following these steps:. 1) By using ‘Cross Data Search’ (Figure 1), we search relationships between ‘protein’ (Component A) and ‘neurobiological system, brain morphology and function, cognition and behavior, symptoms and signs’ (Component B). There are a total of 144 results. BDNF protein and BDNF.

3

MK4MDD

http://mdd.psych.ac.cn/upload.do

MK4MDD aims to offer research community a comprehensive resource and analysis platform for MDD research. The keywords for paper search is described in " Literature search and data extraction. Upload search keywords or term. Upload articles or relationships. Brain morphology and function. Brain morphology and function. To view this website normally, please make sure to allow Flash to run from the local filesystem in the security settings panel. Last update: October 10, 2015.

4

MK4MDD

http://mdd.psych.ac.cn/tutorial.do

3 My Relationship Set. 4 Potential Biomarkers Search. 5 An Example on How to Explore MK4MDD to Generate Hypothesis. 6 Download and Upload. There are several search options to facilitate users to access and browse the MDD data network (Figure 1):. 1) Multi-level Search on the homepage. To search published reports of a component of interest in all the 7 research levels. 2) Advanced Search - Genetic/Epigenetic Locus Search. Genetic/Epigenetic Locus Search Example. 3) Advanced Search - Cross Data Search.

5

MK4MDD

http://mdd.psych.ac.cn/EntityList2.do?type=rs&order=research_count&direction=desc

No of Studies (Positive/Negative). ChrCHR HSCHR17 2 CTG5:45829832(Forward). ChrCHR HSCHR17 2 CTG5:45814295(Forward). ChrCHR HSCHR5 3 CTG1:1437345(Reverse). ChrCHR HSCHR1 3 CTG32 1:243500591(Forward). ChrCHR HSCHR6 MHC SSTO CTG1:31565999(Forward). ChrCHR HSCHR6 MHC SSTO CTG1:31006939(Forward). ChrCHR HSCHR6 MHC SSTO CTG1:31705013(Forward). ChrCHR HSCHR9 1 CTG1:7500155(Forward). ChrCHR HSCHR17 2 CTG5:45819620(Forward). ChrCHR HSCHR11 1 CTG7:2768933(Forward). Last update: October 10, 2015.

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bioinfo.psych.ac.cn bioinfo.psych.ac.cn

Bioinformatics Lab, Institute of Psychology, CAS

http://bioinfo.psych.ac.cn/EN/index.jsp

GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. ICSNPathway: Identify candidate Causal SNPs and Pathways from genome-wide association study by one analytical framework. Gene Set Enrichment Analysis for Genome-Wide Association Study. RVarBase: an Updated Database for Regulatory Features of Human Variants. RSNPBase: A Database for Curated Regulatory SNPs. MK4MDD: Multi-level Knowledge Base for Major Depressive Disorder.

adhd.psych.ac.cn adhd.psych.ac.cn

ADHDgene Database

http://adhd.psych.ac.cn/aboutus.do

Search Variant with Study. Search Gene with Study. Search Region with Study. Genome-wide Association Studies of ADHD. Genome-wide Linkage Studies of ADHD. Genome-wide CNV Analyses of ADHD. Meta-analysis Studies of ADHD. Pathway by PBA: 8. Our team ( http:/ bioinfo.psych.ac.cn/EN/index.jsp. GSEA4GWAS (2010) and ICSNPathway (2011). For the pathway-based analysis (PBA) performed in ADHDgene, we used a PBA algorithm, named i. If you have any questions while using the site, please feel free to Contact Us.

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BDgene Database

http://bdgene.psych.ac.cn/data.do

Core Gene from Gene Prioritization. Pathways from PBA (Pathway-based Analysis). Enriched Pathways for Core Genes. Enriched Pathways for Cross-disorder Genes. Search Gene with Disease. Search Gene1 with Disease. 11 BD genetic factors. BDgene contains multi-type BD-related genetic factors extracted from 918 studies. Category statistics of BD related genetic factors were shown in Table 1. Data content and statistics of BD related genetic factors in BDgene (by March 31, 2016). Bipolar" [Title/Abstract] OR "m...

bdgene.psych.ac.cn bdgene.psych.ac.cn

BDgene Database

http://bdgene.psych.ac.cn/BDMDD_gene.do

Core Gene from Gene Prioritization. Pathways from PBA (Pathway-based Analysis). Enriched Pathways for Core Genes. Enriched Pathways for Cross-disorder Genes. Search Gene with Disease. Search Gene1 with Disease. BD and MDD shared genes. Total unique gene count: 236. For BD-MDD shared genes, genes from cross-disorder studies about BD-MDD or BD-SZ-MDD were considered from cross-disorder studies, genes from intersection analysis of BDgene and MK4MDD. From cross-disorder studies (count: 139). Spectrin repeat ...

bioinfo.psych.ac.cn bioinfo.psych.ac.cn

中国科学院心理所生物信息实验室

http://bioinfo.psych.ac.cn/CN/Our_db.jsp

Zhang, K.L.*, Chang, S.H.*, Guo, L.Y., Wang, J. (2014) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Zhang, K.L, Chang, S.H., Cui, S.J., Guo, L.Y., Zhang, L.Y., and Wang, J., 2011 ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res. 42 (D1): D1033-D1039. doi: 10.1093/nar/gkt1167. Guo, L., Zhang, W., Chang, S., Zhang, ...Zhang, L&...

bdgene.psych.ac.cn bdgene.psych.ac.cn

BDgene Database

http://bdgene.psych.ac.cn/tutorial.do

Core Gene from Gene Prioritization. Pathways from PBA (Pathway-based Analysis). Enriched Pathways for Core Genes. Enriched Pathways for Cross-disorder Genes. Search Gene with Disease. Search Gene1 with Disease. 2 Disease Gene Overlap. 41 My Gene Set. In BDgene, handy and powerful ways for data searching and browsing are provided for users. Apart from the ' Search. Bar on the home page which presents regular keyword search option, the ' Advanced Search. Options for gene search and gene search result.

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MK4MDD

Multi-level Knowledge base for Major Depressive Disorder (MK4MDD). Is an innovative informatics tool to integrate different levels of data in published MDD experimental studies and show the dynamic interplay of components in pathophysiological cascade of MDD. MK4MDD has three notable features:. An example on how to explore MK4MDD. A tutorial for database usage. BDNF, Dopamine, Amygdala or directly search to get all components at different level. Protein and other molecule. Cell and molecular pathway.

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