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Marles-Wright Laboratory | Structural and Synthetic Biology

Structural and Synthetic Biology. The major potential impacts of our research are related to the development of modular systems based on bacterial compartments for use in industrial biotechnology including: 1. platforms designed for the production of toxic proteins within compartments; 2. encapsulation of biosynthetic pathways for valuable natural products to minimize loss of intermediates and maximize metabolic efficiency; 3. use of compartments in bio-mining and bio-remediation for the sequ...

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Marles-Wright Laboratory | Structural and Synthetic Biology | perutz.bio.ed.ac.uk Reviews
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Structural and Synthetic Biology. The major potential impacts of our research are related to the development of modular systems based on bacterial compartments for use in industrial biotechnology including: 1. platforms designed for the production of toxic proteins within compartments; 2. encapsulation of biosynthetic pathways for valuable natural products to minimize loss of intermediates and maximize metabolic efficiency; 3. use of compartments in bio-mining and bio-remediation for the sequ...
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Marles-Wright Laboratory | Structural and Synthetic Biology | perutz.bio.ed.ac.uk Reviews

https://perutz.bio.ed.ac.uk

Structural and Synthetic Biology. The major potential impacts of our research are related to the development of modular systems based on bacterial compartments for use in industrial biotechnology including: 1. platforms designed for the production of toxic proteins within compartments; 2. encapsulation of biosynthetic pathways for valuable natural products to minimize loss of intermediates and maximize metabolic efficiency; 3. use of compartments in bio-mining and bio-remediation for the sequ...

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1

Streptoccus mutans sortase A structure | Marles-Wright Laboratory

http://perutz.bio.ed.ac.uk/blog/2015/05/23/srta

Structural and Synthetic Biology. Streptoccus mutans sortase A structure. This work was funded in part by the Wm. Wrigley Jr. Company. We recently determined the structure of the Streptococcus mutans. Sortase A protein in collaboration with the Campopiano. Chalcone is a member of a huge family of flavonoid natural products that are found in liquorice and turmeric root to name just a few sources. In this paper we use biochemical assays and mass spectrometry to show that. May 23, 2015. Moving day →. Help, ...

2

May | 2015 | Marles-Wright Laboratory

http://perutz.bio.ed.ac.uk/blog/2015/05

Structural and Synthetic Biology. Monthly Archives: May 2015. Streptoccus mutans sortase A structure. This work was funded in part by the Wm. Wrigley Jr. Company. We recently determined the structure of the Streptococcus mutans. Sortase A protein in collaboration with the Campopiano. Chalcone is a member of a huge family of flavonoid natural products that are found in liquorice and turmeric root to name just a few sources. In this paper we use biochemical assays and mass spectrometry to show that. Colleg...

3

Publications | Marles-Wright Laboratory

http://perutz.bio.ed.ac.uk/publications

Structural and Synthetic Biology. Tuck LR, Altenbach K, Ang TF, Crawshaw AD, Campopiano DJ, Clarke DJ, Marles-Wright J. Insight into Coenzyme A cofactor binding and the mechanism of acyl-transfer in an acylating aldehyde dehydrogenase from Clostridium phytofermentans. Wallock-Richards DJ, Marles-Wright J, Clarke DJ, Maitra A, Dodds M, Hanley B,. Campopiano DJ. Molecular basis of Streptococcus mutans sortase A inhibition by. The flavonoid natural product trans-chalcone. Natl Acad Sci U S A. Harris JR, Cal...

4

Open for Science | Marles-Wright Laboratory

http://perutz.bio.ed.ac.uk/blog/2013/03/01/open-for-science

Structural and Synthetic Biology. Now that the Marles-Wright Laboratory is no longer a ‘virtual’ lab, in the sense that it isn’t just me and a laptop anymore, now seems like a good time to put out a little introduction and set out the scientific culture I’d like to foster as an independent researcher and lab head. Since starting my Chancellor’s Fellowship in Edinburgh, I’m lucky to have found and employed a really promising RA and managed to secure funding for an EASTBio. To name only a few active advoca...

5

Teaching | Marles-Wright Laboratory

http://perutz.bio.ed.ac.uk/teaching

Structural and Synthetic Biology. Jon currently teaches on the following courses at Edinburgh University. Molecules Genes and Cells. 8211; 1st year course (tutorials). 8211; 2nd year course (Course Organiser 2014/2015). We offer laboratory projects to 4th year students on Biochemistry and Biotechnology honours courses. MSc in Systems and Synthetic Biology. Tools for Synthetic Biology. Applications of Synthetic Biology. Biochemistry A, Practical Skills in biochemistry A. Help, I’m a Scientist!

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Marles-Wright Laboratory | Structural and Synthetic Biology

Structural and Synthetic Biology. The major potential impacts of our research are related to the development of modular systems based on bacterial compartments for use in industrial biotechnology including: 1. platforms designed for the production of toxic proteins within compartments; 2. encapsulation of biosynthetic pathways for valuable natural products to minimize loss of intermediates and maximize metabolic efficiency; 3. use of compartments in bio-mining and bio-remediation for the sequ...

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