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Pharmacodynamics – Chronic CVS Effects. Cardiac disease is the leading cause of death in connection with chronic alcohol abuse due to congestive dilated. Cardiomyopathy. This disease is typically preceded by a decade of ingesting 80 gm of alcohol daily. Chronic heavy drinking. Can cause cardiomyopathy with symptoms ranging from unexplained arrhythmias in the presence of left ventricular impairment,. As the “Holiday Heart Syndrome”. Although the mechanism for this hypertension is not clear. Conduction def...
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http://www.gasnet.org/pharmacodynamics-acute-cvs-effects
Pharmacodynamics – Acute CVS Effects. Acute Effects of Alcohol on the Cardiovascular System: Acute effects of alcohol on the circulation are minor. With. Moderate amounts of alcohol there is little change in the blood pressure, cardiac output or force of myocardial. Contraction. However, vasodilation, which results in a warm, flushed skin does occur. Acute, severe alcoholic intoxication. Causes cardiovascular depression due to central vasomotor effects and respiratory depression.
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http://www.gasnet.org/pharmacodynamics-kidneys
Pharmacodynamics – Kidneys. Alcohol exerts a diuretic effect by inhibiting the secretion of antidiuretic hormone. The diuretic effect is proportional. To the blood alcohol concentration and occurs only when the concentration is rising. When the blood alcohol concentration. Is falling, it acts as an antidiuretic. Serum sodium may be slightly increased and potassium decreased in chronic alcoholics. These patients also have increased. Pharmacokinetics – Metabolism. Pharmacodynamics – Pulmonary System.
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Pharmacokinetics – Metabolism. Alcohol is metabolized to acetaldehyde via two pathways. The main pathway for alcohol metabolism is the alcohol. Dehydrogenase pathway, which is located mainly in the liver. Alcohol dehydrogenase is a cytosolic enzyme that catalyzes the. Conversion of alcohol to acetaldehyde. Alcohol dehydrogenase is also found in the stomach, but to a lesser extent in women than in men. Again, resulting in women. Achieving a higher blood alcohol level than men when given the same dose.
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http://www.gasnet.org/pharmacodynamics-nutrition
Pharmacodynamics – Nutrition. Any vitamin absorbed through the small intestine by active transport or stored in the liver may be deficient in even. Apparently well nourished alcoholics. Such vitamins include folate, pyridoxine (B6), thiamine (B1), nicotinic acid (niacin,. B3) and vitamin A. Nicotinic acid deficiency causes pellagra. Thiamine deficiency causes Beriberi, Wernicke’s. Intramuscularly daily until a normal diet is resumed. Blood cell and platelet dysfunction, brain dysfunction and weakness of ...
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http://www.gasnet.org/pharmacokinetics-kinetics-drug-interactions
Pharmacokinetics – Kinetics & Drug Interactions. Elimination of ethanol follows mostly zero order kinetics, which means that the rate of elimination (7 to 10 g/h) is. Independent of the concentration of ethanol in the blood. For a typical adult, blood alcohol concentration declines at a. Rate of 15 mg/dl per hour. This amounts to about one standard drink per hour. The rate of alcohol metabolism is faster in. The effects of hypoglycemic drugs and enhance aspirin induced gastritis.
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