According to the CiPA initiative, SCAP Test highlights compound cardiac risks (EAD facilitation, triangulation, RUD, TDR, APD increase, Vmax decrease,...) by in silico computational modeling
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Safe Cardiac Action Potential Test (scap test) | scaptest.com Reviews
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According to the CiPA initiative, SCAP Test highlights compound cardiac risks (EAD facilitation, triangulation, RUD, TDR, APD increase, Vmax decrease,...) by in silico computational modeling
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Safe Cardiac Action Potential Test. Provide your account details to create a new temporary password for your account. New: vardenafil in silico cardiac safety profile (August 28, 2016). New: lacosamide in silico cardiac safety profile (August 16, 2016). Safe Cardiac Action Potential Test (SCAP Test).
Effect of cardiac currents on the in silico action potential
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Safe Cardiac Action Potential Test. New: vardenafil in silico cardiac safety profile (August 28, 2016). New: lacosamide in silico cardiac safety profile (August 16, 2016). Safe Cardiac Action Potential Test (SCAP Test).
Cardiac action potential simulation can reduce drug attrition earlier, faster and cheaper by Safe Cardiac action potential test
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Safe Cardiac Action Potential Test. Non cardiac drugs can unintentionally interfere with cardiac electrophysiology and pose risks of arrhythmogenicity. This c. Is a major concern for pharmaceutical industry, regulatory agencies and society, having a huge socio-economic impact. Identification of cardiotoxic compounds as early as possible. In the drug research and development process is mandatory. As attested by the high attrition rate. Omplexity of the mechanisms of drug-induced pro-arrhythmia and the e.
in silico cardiac action potential simulation models
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Safe Cardiac Action Potential Test. These links describe the various in silico computational models we used to perform cardiac action potential simulation. Guinea pig: Luo and Rudy (1994). Rabbit : Shannon and al. (2004). Dog : Hund and Rudy (2004). Human : Grandi and al. (2010). O’Hara and al. (2011). Rabbit : Aslanidi and al. (2010). Dog : Aslanidi and al. (2009). Human : Stewart and al. (2009). Sampson and al. (2010). Rabbit : Aslanidi and al. (2009). Dog : Xia et al. (2010).
in silico cardiac action potential and safety pharmacology
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Safe Cardiac Action Potential Test. Computational simulation (O Hara-Rudy dynamic model), the effects of various drugs on the cardiac action potential of the human endo-, mid- and epi-cardial myocytes have been tested in order to evaluate their cardiac safety pharmacology profiles. For this purpose, the conductance of various cardiac channels was changed in the ORd algorithm by a scaling factor which was a function of the IC. Mirams et al, 2014. Okada et al, 2015. Obejero-Paz et al, 2015. New: vardenafil...
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Safe Cardiac Action Potential Test | CROmpare
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Skip to main content. The CRO Comparison Engine. Log in using OpenID. Log in using OpenID. Safe Cardiac Action Potential Test. Submitted by CROmpare.com. On Mon, 03/24/2014 - 17:49. B-1367 Grand Rosière Hottomont. 32 498 76 35 90.
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Safe Cardiac Action Potential Test (scap test)
Safe Cardiac Action Potential Test. Computational modeling and simulation. In accordance with the CiPA initiative,. Helps you to determine. The cardiac risks of your compounds. Early afterdepolarisation facilitation (EAD). Reverse use dependence (RUD). Transmural dispersion of repolarisation (TDR). Action potential duration (APD) : prolongation or shortening. Maximal rate of AP rise: V. Computational modeling and simulation. Safe Cardiac Action Potential Test (SCAP Test).
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