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harkerbio.com

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https://www.harkerbio.com/x-ray-structure-determination

Three-Dimensional Crystallographic Structure Determination. HarkerBIO research team provides a full suite of services to help you solve difficult structures with speed and accuracy. We utilize state of the art software, augmented by decades of solution and refinement experience, to rapidly solve crystal structures of macromolecules and complexes. We have access to several high-brilliance synchrotron beam lines at APS and CLS - as well as access to SSRL via a partner company. Type Code Above Into This Box.

harkerbio.com

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https://www.harkerbio.com/protein-production

Protein Production, Purification and Characterization. Protein production is an integral component of the gene-to-structure pipeline at HarkerBIO - and it is also available to our customers and collaborators as a standalone item, or in combination with other services. It is important to note that our service provides crystallization grade protein, which is eminently suitable for crystallization or for activity assays, etc. We stand behind every protein we deliver! Sf-9 cells) baculovirus-infected cells.

harkerbio.com

Current News Articles

https://www.harkerbio.com/news

HarkerBIO and AMRI sign Collaborative Agreement. Sat, Aug 1st 2015 10:00 pm. AMRI and HarkerBIO sign collaborative agreement to co-market structure-based drug discovery services. Dr Artem Evdokimov joins HarkerBIO as CSO. Mon, Jul 20th 2015 03:00 pm. Dr Artem Evdokimov joined HarkerBIO in late July 2015 as Chief Scientific Officer. Type Code Above Into This Box. HarkerBIO, L.L.C.,. 700 Ellicott Street,. Buffalo, NY 14203. Powered by Fission Content Management System.

harkerbio.com

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https://www.harkerbio.com/drug-discovery

Harker's expertise in structure-based drug discovery using fragment-based approaches acclerates lead discovery to drug optimization. Drug discovery is enhanced with complementary expertise in computational molecular docking and homology modeling. Through our collaboration with AMRI we offer a number of compound libraries for screening and selection. We can also use client-supplied libraries (fragments or full-sized molecular scaffolds) for parallel co-crystallization or soaking. 700 Ellicott Street,.

harkerbio.com

HarkerBIO

https://www.harkerbio.com/sonic-blurb

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) is a commercial technology marketed by Formulatrix, Inc. The basis for the SONICC process is the generation of second-order harmonic light when chiral crystals are irradiated by an ultrafast laser source that is rapidly scanning across a drop by means of piezo-driven micro-mirrors. Incident light can be effectively filtered away from the emergent second-harmonic light (which has twice the frequency of the incident light! Within the HarkerBIO gene...

harkerbio.com

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https://www.harkerbio.com/gene-to-structure

HarkerBIO gene-to-structure pipeline is available to you for immediate deployment: all you need to do is provide us with the amino acid sequence of the gene(s) of interest, and we do the rest! We use proprietary computational methods and decades of human experience to design constructs that enhance the probability of crystallization. For each customer sequence we typically design 8-24 constructs in order to enhance the target's crystallization potential. Secondary Screening - Medium-Throughput, all major...

harkerbio.com

The Team @ HarkerBIO

https://www.harkerbio.com/history-bios

Was founded in 2014 as a spin-off of the Hauptman-Woodward Medical Research Institute. Our mission is to work with clients to improve and optimize the process of drug discovery through Structural Biology. Dr Artem Evdokimov joined HarkerBIO in late July 2015 as Chief Scientific Officer. Artem received a dual PhD in Chemistry and Structural Biology from the Weizmann Institute of Science in Israel. He then spent two years at the National Institutes of Health ( NCI-Frederick. Where he studied Yersinia pestis.

harkerbio.com

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https://www.harkerbio.com/protein-optimization

Protein OPTIMIZATION / PROTEIN DESIGN. If you have an enzyme activity that you'd like to optimize we can execute a Design Campaign for you - to increase the activity towards your target values (Vmax, Km, or Vmax/Km criteria). We have proven methods for thermal and/or proteolytic stability optimization/li. We can enhance the stability of a macromolecular complex (protein-protein, protein-ligand, or protein-DNA), or we can help you optimize its specificity/selectivity. We are ready to listen to your needs!