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TiCo - TIS Correction

TiCo is a tool for postprocessing predictions of prokaryotic genes with the objective to improve the accuracy of annotated Translation Initiation Sites (TIS). Currently the tool can be used to analyze and reannotate predictions obtained by the program GLIMMER2.x (Delcher. TiCo provides a GLIMMER-like output which contains the relocated gene starts together with some information for the evaluation of the quality of the corresponding TIS. The results are also available in GFF (. Form to TiCo's web interface.

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TiCo - TIS Correction | tico.gobics.de Reviews
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TiCo is a tool for postprocessing predictions of prokaryotic genes with the objective to improve the accuracy of annotated Translation Initiation Sites (TIS). Currently the tool can be used to analyze and reannotate predictions obtained by the program GLIMMER2.x (Delcher. TiCo provides a GLIMMER-like output which contains the relocated gene starts together with some information for the evaluation of the quality of the corresponding TIS. The results are also available in GFF (. Form to TiCo's web interface.
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2 introduction
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4 online submission
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TiCo - TIS Correction | tico.gobics.de Reviews

https://tico.gobics.de

TiCo is a tool for postprocessing predictions of prokaryotic genes with the objective to improve the accuracy of annotated Translation Initiation Sites (TIS). Currently the tool can be used to analyze and reannotate predictions obtained by the program GLIMMER2.x (Delcher. TiCo provides a GLIMMER-like output which contains the relocated gene starts together with some information for the evaluation of the quality of the corresponding TIS. The results are also available in GFF (. Form to TiCo's web interface.

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1

The TiCo algorithm

http://tico.gobics.de/algorithm.jsp

Classification of Candidate TIS Sequences. Our method is based on the analysis of candidate TIS sequences as obtained from the flanking regions of potential start codons. We implemented a clustering algorithm which performs an unsupervised classification of sequences according to. TIS and all other candidates within the same search range as. Starting with the above initial classification we iterate the following two successive steps:. Inhomogeneous second order probabilities models for the. TIS, all othe...

2

WeightsVis - Visualization of the weights matrix

http://tico.gobics.de/weights.jsp

Visualization of a weights matrix. WeightsVis-Visualization of the positional weights matrix (PWM) calculated by TiCo for E. coli. With the default parameters. The weights are provided with the TiCo-prediction (attached to the results-email for users of the web interface or written to the output directory of the stand-alone version). The tool WeightsVis is available from our download site. A short description of the usage is given in the README.

3

TiCo - Download

http://tico.gobics.de/download.jsp

Free download of TiCo stand-alone version. Download Datasets (tarball, 12 MB). Linux release of TiCo - Complete package. The complete packages contain:. Jars of TiCo 2.1 and Log4j (plus Mail and Activation for the version with mail interface). Matlab Libraries for Linux. Matlab compiler generated program for Linux. Configuration files for Linux. Matlab visualization program with bash starter script. TiCo21 (all inclusive) - with mail interface. TiCo21 (all inclusive) - with mail interface. Gsf2coord: Con...

4

TiCo - TIS Correction help page

http://tico.gobics.de/help.jsp

Input and output formats. A description of the input and output formats with examples can be found here. The following parameters are provided to adjust the consideration of alternative start sites for a putative gene. The parameter sigma is used to smooth the positional probability Markov Models. TIS A potential start site is defined as start codon. That shares the same reading frame of the respective gene, with no inframe stop codon between the start codon and the annotated stop. Of the search range.

5

TiCo - TIS-Correction

http://tico.gobics.de/ioexamples.jsp

Input and output formats]. TiCo input and output formats. For the TiCo prediction two types of input data are necessary. First a file with gene data and second a file with the corresponding nucleotide sequence is needed. The current version of the TiCo webinterface provides the following input and output formats. Sequence in Fasta format. Output in Simple Coord format. TiCo searches the file for the line “ Putative Genes: ” and reads all orfs from there on. Id left right strand[ score][#]. The genome seq...

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Online Analysis Tools - Translation

http://www.molbiol-tools.ca/Translation.htm

A number of excellent sites exist all of which permit translation in all six reading frames. I would recommend ORF Finder because of its visuals and Pipeline or GeneMark if you are seriously interested in identifying genes within your sequence. The latter two programs permit the analysis of long sequences (submit by attachment not in the box). Frameshift errors in DNA sequence - several sites are available. Genio/scan N. Mache). T Schliex et al. 2003. Nucl. Acids Res. 31:. Facilitates the identification ...

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gobics.de: Software

http://gobics.de/department/software

University of Göttingen. Faculty of Biology and Psychology. Institute of Microbiology and Genetics. Software tools available through GOBICS (GÃ ttingen Bioinformatics Compute Server):. Alignment free sequence comparison. A web-server for fast comparative functional profiling of metagenomes. Gene prediction for eukaryotes. Ultra-fast functional profiling of large protein sequence collections. Clustering and Visualization of Metabolic Markers. Multiple sequence alignment; various program versions available.

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TiCo - TIS Correction

TiCo is a tool for postprocessing predictions of prokaryotic genes with the objective to improve the accuracy of annotated Translation Initiation Sites (TIS). Currently the tool can be used to analyze and reannotate predictions obtained by the program GLIMMER2.x (Delcher. TiCo provides a GLIMMER-like output which contains the relocated gene starts together with some information for the evaluation of the quality of the corresponding TIS. The results are also available in GFF (. Form to TiCo's web interface.

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