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A blog about Science. In 2007, I published my second paper [2]. It was a cellular automaton model of carcinogenesis and, in my opinion, my second best paper *. In 2014, Alexandre Sarmento (from Brazil) asked me for the code. Of course I’d lost it. But, amazingly, I’d emailed it to Ornella Cominetti (Chile) back in 2008, and she still had our correspondence. I considered emailing all my code to Ornella, but instead futureproofed my work by setting up a GitHub account. This entry was posted in Uncategorized.
Unfinished Business #4: modelling β-oxidation | U+003F
https://u003f.wordpress.com/2015/03/31/unfinished-business-4-modelling-β-oxidation
A blog about Science. Unfinished Business #4: modelling β-oxidation. I have a long-running. Collaboration with Bernard Corfe. Modelling metabolism of dietary fibres in the gut. These otherwise indigestible carbohydrates are first fermented by bacteria in the colon to form short-chain fatty acids. The fatty acids are then taken up by colonocytes, and processed in their mitochondria using β-oxidation. But, for those not fortunate enough to have a 6.4M grant. You can grab an SBML. Diabetic neuropathy →.
Striking a balance with Recon 2.1 | U+003F
https://u003f.wordpress.com/2014/02/06/striking-a-balance-with-recon-2-1
A blog about Science. Striking a balance with Recon 2.1. In 2013, after years of work, a comprehensive reconstruction. Of human metabolism, called “ Recon 2. 8220;, was released to much. But, as with any many-cooked project, some errors slipped through. The biggest issue I encountered involves unbalanced reactions and generic metabolites. Here are three reactions from the model:. Generic fatty acid R-group. Transfer from CoA (C. Specific to generic reaction, converting C. CoA to R CoA. The new model is a...
Unfinished Business #3: evolving metabolic networks | U+003F
https://u003f.wordpress.com/2015/03/30/unfinished-business-3-evolving-metabolic-networks
A blog about Science. Unfinished Business #3: evolving metabolic networks. As a collection of edges. It would be incredibly useful to have an algorithm that generates a metabolic network structure for a given number of metabolites. The easy way to do this is to take a pan-organism super-network like Kegg. What rules would we use to evolve these networks? Unlike graphs, these metabolic models must satisfy mass-balancing, which can be written as a matrix equation [4]. I anticipate that growing metaboli...
Unfinished Business #2: Who’s afraid of the big bad model? | U+003F
https://u003f.wordpress.com/2015/03/26/unfinished-business-2-whos-afraid-of-the-big-bad-model
A blog about Science. Unfinished Business #2: Who’s afraid of the big bad model? As well as developing and maintaining metabolic reconstructions of yeast. Cells, Pedro Mendes. And I created an algorithm [1] for turning these static networks into dynamic kinetic models. We include any known parameters, and guesstimate the remainder. But how the (frequentist) statisticians amongst you may well ask can we create a model with thousands of parameters, when we only have measurements for tens? Whole-cell models...
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WM in Nottwil (SUI). Ohne Grenzen Folge 39. Ohne Grenzen Folge 36. Das Beste fürs Land. Ich lebe zwei Mal. Chaotischer Formtest vor der WM. RSC heindl "Bewegungsmelder" (Ausgabe #81). Ich lebe zwei Mal. Wie schafft man es, sich realistische aber auch hohe Ziele zu setzen und diese zu erreichen? Wie überwindet man Krisen und Probleme? Wie kann man seine Gedankenkraft für sich arbeiten lassen? Ein Ziel, ist kein Ziel,. Wenn man am Weg stecken bleibt. Ich lass mich nicht behindern.
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U+003F | A blog about Science
A blog about Science. Transcript to flux methods. Last year, Daniel Machado and Marcus Herrgård. Published a great paper [1] evaluating different methods for mapping from transcript data to flux patterns. Flux predictions for eighteen methods were compared to three. The methods varied widely their requirements: continuous vs. discrete levels (10. Cell vs. high/low) and absolute vs. relative expression (10. Cell vs. twice as much as a reference condition). I wouldn’t say that Daaaaave. With growth. It...
2017新118图库开奖结果直播_【2107年马报资料】
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Salta al contenuto principale. Scuola di Scienze Umanistiche. Bandi e Borse Post-laurea. Corsi di Laurea Triennale. Corsi di Laurea Magistrale. Primi passi in Università. Tarm (Test di Accertamento dei Requisiti Minimi). Il Colloquio di lavoro. Carta dei servizi OTP. Tutti i servizi on line. Orientamento: punto estivo e accoglienza matricole. Primi passi all'Università. Test di Accertamento dei Requisiti Minimi: calendario. Domanda ammissione preliminare lauree Magistrali. Focus politiche di Ateneo.
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