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Vendruscolo Lab - Software :: Homeprotein prediction webserver
http://www-mvsoftware.ch.cam.ac.uk/
protein prediction webserver
http://www-mvsoftware.ch.cam.ac.uk/
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Vendruscolo Lab - Software :: Home | www-mvsoftware.ch.cam.ac.uk Reviews
https://www-mvsoftware.ch.cam.ac.uk
protein prediction webserver
The Vendruscolo Laboratory
http://www-vendruscolo.ch.cam.ac.uk/index.html
Centre for Misfolding Diseases. Our research is aimed at understanding the molecular origins of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, and at opening in this way novel opportunities for drug discovery to prevent, delay or treat these conditions. We have set up an interdisciplinary approach that brings together concepts and methods from chemistry, physics, engineering, genetics and medicine, using a combination of in silico, in vitro and in vivo approaches. A rational...
The Vendruscolo Laboratory
http://www-vendruscolo.ch.cam.ac.uk/people.html
Centre for Misfolding Diseases. Postdoc (faa25@cam.ac.uk). Postdoc (mb2006@cam.ac.uk). PhD Student (anb39@cam.ac.uk). Postdoc (cc536@cam.ac.uk). MPhil Student (skrc2@cam.ac.uk). Postdoc (fe237@cam.ac.uk). PhD Student (rf389@cam.ac.uk). PhD Student (bf267@cam.ac.uk). Visiting Professor (stefano.gianni@uniroma1.it). PhD Student (pj291@cam.ac.uk). Postdoc (pk397@cam.ac.uk). Postdoc (jh884@cam.ac.uk). MPhil Student (gthh3@cam.ac.uk). Postdoc (gp388@cam.ac.uk). PhD Student (ps589@cam.ac.uk).
The Vendruscolo Laboratory
http://www-vendruscolo.ch.cam.ac.uk/publications.html
Centre for Misfolding Diseases. P Flagmeier, G. Meisl, M. Vendruscolo, T. P. J. Knowles, C. M. Dobson, A. K. Buell and C. Galvagnion. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of alpha-synuclein aggregation. Proc Natl. Acad. Sci. USA, in press. G Fusco, T. Pape, P. Mahou, P. Arosio, A. Rita Costa, G. Kaminski-Schierle, M. Vendruscolo, G. Veglia, C. M. Dobson and A. De Simone. Structural basis of synaptic vesicle assembly promoted by alpha-synuclein.
The CamSol method for protein solubility prediction
http://www-vendruscolo.ch.cam.ac.uk/camsolmethod.html
The CamSol solubility score is tested against experimentally determined solubility changes upon mutation from the literature. The testing set contains 56 different protein variants from 19 wild type proteins and includes some antibodies. The bar plot reports the fraction of correctly predicted solubility changes upon mutation using CamSol and two methods of predicting solubility upon over-expression that are SOLpro, and PROSO II. See Reference 1 for details. Identification of self-assembly hotspots.
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Vendruscolo Lab - Software :: Home
Vendruscolo Lab - Software. A method of calculating secondary structures populations of proteins from their chemical shifts. A method the prediction of protein secondary structure populations from the amino acid sequence, which predicts simultaneously structure and intrinsic disorder. It includes polyproline-II prediction. ( paper. A method of rational design of protein variants with enhanced solubility, which includes a prediction of protein solubility scores and solubility profiles ( more info. This we...
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