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Drug Truths | A site devoted to teaching about drug discovery and development.A site devoted to teaching about drug discovery and development.
http://johnlamattina.wordpress.com/
A site devoted to teaching about drug discovery and development.
http://johnlamattina.wordpress.com/
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Drug Truths | A site devoted to teaching about drug discovery and development. | johnlamattina.wordpress.com Reviews
https://johnlamattina.wordpress.com
A site devoted to teaching about drug discovery and development.
johnlamattina.wordpress.com
When It Comes to NDA Approvals, Is 30 the New 50? | Drug Truths
https://johnlamattina.wordpress.com/2012/01/17/when-it-comes-to-nda-approvals-is-30-the-new-50
A site devoted to teaching about drug discovery and development. When It Comes to NDA Approvals, Is 30 the New 50? As an aside, the user fee in 1995 for a full NDA was $208,000. In 2012, the fee is $1,841,500. Considering that fewer NDAs are being filed, given the nine-fold increase in PDUFA user fees, one might wonder why all drugs can’t be approved with a six months review time.). Suggests that only 50% of compounds entering Phase 3 get FDA approval. Phase 3, which prior to 2000 served to confirm r...
Are Older Women on Statins at Risk For Diabetes? | Drug Truths
https://johnlamattina.wordpress.com/2012/01/24/are-older-women-on-statins-at-risk-for-diabetes
A site devoted to teaching about drug discovery and development. Are Older Women on Statins at Risk For Diabetes? A few days later, I received a comment that began: Did none of you receive the message that statin use was associated with the onset of type 2 diabetes? The writer was referring to recent data from the Women’s Health Initiative (WHI) reported in the online edition of Archives of Internal Medicine. Does this mean that statins can make older women more susceptible to diabetes? Vol 364, 685 696,...
Disease Creep or Good Medical Practice? | Drug Truths
https://johnlamattina.wordpress.com/2012/01/04/disease-creep-or-good-medical-practice
A site devoted to teaching about drug discovery and development. Disease Creep or Good Medical Practice? The American Heart Association has been monitoring deaths due to cardiovascular disease (CVD) in the U.S. for over a century. While the CVD death rate grew steadily for most of the 20. Thus, it is stunning to see an essay like Jeanne Lenzer’s Disease Creep: How we’re fooled into using more medicine than we need. December 22, 2011). Lenzer’s views can be summarized in her quote below:. Laquo; The Peril...
Indian Companies Are Finding Drug R&D Pitfalls | Drug Truths
https://johnlamattina.wordpress.com/2012/01/09/indian-companies-are-finding-drug-rd-pitfalls
A site devoted to teaching about drug discovery and development. Indian Companies Are Finding Drug R&D Pitfalls. A brief article in. January 2, 2012) entitled Zydus, Eli Lilly drug discovery deal off. Developing a new drug from scratch is getting more expensive due to increased regulatory scrutiny and high costs of clinical trials. Lowering costs through a partnership with an Indian drug firm was one way of speeding up the process, but the success rate has not been very high. If not, they will need a maj...
The Generosity of Drug Companies | Drug Truths
https://johnlamattina.wordpress.com/2012/02/01/the-generosity-of-drug-companies
A site devoted to teaching about drug discovery and development. The Generosity of Drug Companies. At a major press conference this week, the Bill and Melinda Gates Foundation. And 13 drugmakers, along with the World Bank, the US, Britain, and UAE, announced a joint effort to attack 10 neglected tropical diseases. But, for the pharmaceutical companies involved, this isn’t something new. Aimed at improving the plight of those suffering in the developing world. February 1, 2012 at 9:57 am. Laquo; Are Older...
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Omics! Omics!: February 2014
http://omicsomics.blogspot.com/2014_02_01_archive.html
A computational biologists personal views on new technologies and publications on genomics and proteomics and their impact on drug discovery. Wednesday, February 26, 2014. NGS Saves A Young Life. Links to this post. Monday, February 24, 2014. A Sunset for Draft Genomes? Links to this post. Thursday, February 13, 2014. How will you deal with GRCh38? So, a significant advance, but a bit unpleasant one if you are in the space. You now have several ugly options before you with regard to your prior data m...
Omics! Omics!: June 2015
http://omicsomics.blogspot.com/2015_06_01_archive.html
A computational biologists personal views on new technologies and publications on genomics and proteomics and their impact on drug discovery. Tuesday, June 30, 2015. June 2015: Busting Out All Over with Genomics Technology. 10X Genomics and a pair from Oxford Nanopore. Links to this post. Monday, June 08, 2015. BGI Unveils a Sequencing Factory to Go. When I was in George Churchs lab, he submitted a grant proposal (which, alas, was not funded) for a sequencing factory to generate one megabase. The Ion Tor...
sussexdrugdiscovery.wordpress.com
October | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/10
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: October 2014. Alzheimer’s in a dish’ – A 3D cell culture model of Alzheimer’s disease. October 20, 2014. This month a group in the US have published an elegant study. Amyloid-β deposits in control (ReN-G) and FAD ReN (ReN-mGAP). This important work has not only provided experimental evidence supp...
sussexdrugdiscovery.wordpress.com
November | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/11
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: November 2014. In Silico Prediction of Off Target Activities of Chemical Probes. A recent publication highlights the importance of assessing broad selectivity and describes an in silico approach capable of predicting off target liabilities ( Antolín and Mestres, ACS Chemical Biology 2014, ahead o...
sussexdrugdiscovery.wordpress.com
September | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/09
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: September 2014. Can we predict compound precipitation in DMSO stocks? September 28, 2014. To determine if a physicochemical property could be identified as a correlating factor for increased precipitation rate in the Tox set compared to the fragment set , the MW, clogP, fsp3 (fraction of sp3 carb...
sussexdrugdiscovery.wordpress.com
February | 2015 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2015/02
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: February 2015. Toward a future of truly personalized cancer therapy. February 12, 2015. Targeted cancer therapies have produced substantial clinical results in the last decade, but most tumours eventually develop resistance to these drugs. Benes, Engelman and colleagues have recently described in.
sussexdrugdiscovery.wordpress.com
December | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/12
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: December 2014. Highlights from Society of Medicines Research Meeting 4th December 2014. December 16, 2014. The Society for Medicines Research was hosting the Recent Disclosures of Clinical Candidates meeting on Thursday 4. Blood 9.5) whilst showing selectivity over the pro-inflammatory cytoki...
Grasping the Information Explosion to Advantage | R&D Returns
http://www.randdreturns.com/grasping-the-information-explosion-to-advantage
Grasping the Information Explosion to Advantage. Firms increasingly recognize that better, faster use of their information is the key to success. This is even more important to Life Science firms as they address an explosion of data. Their big bang occurred in the past decade, creating new fields like proteomics, metabolonomics, disease modeling, etc., and their new data types. It cannot be stressed enough that this diversity is even more challenging than just an increase in the volume of data. Let’s con...
Omics! Omics!: Clinical Metagenomics Pipelines: Revisiting & Reflecting
http://omicsomics.blogspot.com/2015/07/clinical-metagenomics-pipelines.html
A computational biologists personal views on new technologies and publications on genomics and proteomics and their impact on drug discovery. Friday, July 10, 2015. Clinical Metagenomics Pipelines: Revisiting and Reflecting. Last week's piece concerned an F1000 paper by Steven Salzberg and colleagues which reanalyzed a clinical metagenomics dataset and alleged two serious problems. The first claim was that the software used in the paper failed to detect potential bacterial pathogens in the samples...
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John LaMacchia's Pencils
A Spot to Discover the Perfect Heirloom Gift for Anyone Who Loves. Monday, June 22, 2009. Hello and Welcome to my Blog! Charlize was absolutely one of the cutest little girls on the planet. Her Daddy loved her so and couldn't wait for the drawing to be done. Great likeness! This is about an 8.5x11 image. This work was commissioned by Grandma! The family lives in Texas and the artwork was a. The photo darkened the work just a little.). Thomas Wolfe - One of my favorites! It was a very old, plain photo.
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Drug Truths | A site devoted to teaching about drug discovery and development.
A site devoted to teaching about drug discovery and development. Drug Truths Blog Has Been Moved to Forbes. Leave a comment ». I’ve started blogging for. To continue following “Drug Truths,” please CLICK HERE. If you’ve discovered “Drug Truths” through my. Blog, please feel free to look at my older posts discussing the pharmaceutical industry. February 15, 2012 at 11:00 am. The Generosity of Drug Companies. At a major press conference this week, the Bill and Melinda Gates Foundation. October 10, 2010), J...
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How we are different. We safeguard your financial future through effective financial planning. For you and your family. John Lamb is an independent firm of Chartered Financial Planners established in 1959. We provide expert financial advice to people who want to preserve and grow their wealth responsibly for this generation and the next. It’s impossible to predict the unexpected but we help you plan a secure financial future no matter what happens. Follow us on LinkedIn. 34 Southwark Bridge Road.
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John 'Racka' Lamb. Welcome to my website. I live in the little town of Cohuna in North West Victoria and I am a computer GEEK / NERD: and proud of it! Want to know more about me then click here. I have setup this web page as I a now offering computer help to Cohuna and surrounds. To find out more on how I can help you, check out my Computer Help. Page or even my Web Site Building. So do come back regularly :). Want your computer running as efficiently as possible? Or, perhaps some training? A lot of prog...
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