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COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page

Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

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COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page | cancer.sanger.ac.uk Reviews
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Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...
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COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page | cancer.sanger.ac.uk Reviews

https://cancer.sanger.ac.uk

Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

INTERNAL PAGES

cancer.sanger.ac.uk cancer.sanger.ac.uk
1

COSMIC: Licensing - Frequently Asked Questions ( FAQ )

http://cancer.sanger.ac.uk/cosmic/license/faq

Licensing - Frequently Asked Questions ( FAQ ). What is your main motivation for changing your licensing policy? The new licensing strategy has been developed to grow the COSMIC project to better encompass the range of genetic abnormalities underlying cancer and to make these better available, integrated and analysable. How much will a license for COSMIC cost my organisation annually? What’s the difference between looking at the data on the website and what you get when you download the data? We will soo...

2

COSMIC: COSMIC Publications Page

http://cancer.sanger.ac.uk/cosmic/publications

Our most recent publication: COSMIC: exploring the world's knowledge of somatic mutations in human cancer (Forbes et al. 2014). COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. (Forbes et al. 2011). COSMIC detailed description : The Catalogue of Somatic Mutations in Cancer (COSMIC). (Forbes et al. 2008). Biomart: Data mining using the Catalogue of Somatic Mutations in Cancer BioMart. The Catalogue of Somatic Mutations in Cancer (COSMIC).

3

WGS: Whole genomes project - Home page

http://cancer.sanger.ac.uk/wgs

Whole Genomes v78, released 05-SEP-16. COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Start using COSMIC by searching for a gene, cancer type, mutation, etc. below, or by browsing a region of the human genome using the map to the right. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Whole Genome Sample Browser. ICGC release 21; May 16.

4

COSMIC: Tutorials home page

http://cancer.sanger.ac.uk/cosmic/help/tutorials

If you are new to COSMIC you may find our tutorial videos useful. Genes: Genes with Mutations. Genes: Genes without Mutations. Variants: CNV and Expression. CNV and Expr Details. Variants: CNV and Expr. Drug Resistance: Mutation Details. Variants: CNV and Expression. Variants: CNV and Expression. Whole Genome and Large Scale Sytematic Screens. Wellcome Trust Sanger Institute, Genome Research Limited (reg no. 2742969) is a charity registered in England with number 1021457.

5

COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page

http://cancer.sanger.ac.uk/cancergenome/projects/cosmic

High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. Genomic Landscape of Cancer. All COSMIC services (including website and downloads) will be unavailable from the 26th to 30th August 2016. We do apologise for the disruption to our service and any inconvenience this causes, and recommend that all downloads are completed by 17:00 BST (current UK time) on 26th August. COSMIC now curates drug resistance mutations. In v77; AR.

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ccgd-starrlab.oit.umn.edu ccgd-starrlab.oit.umn.edu

Download the Candidate Cancer Gene Database (CCGD)

http://ccgd-starrlab.oit.umn.edu/download.php

Candidate Cancer Gene Database. To download the entire Candidate Cancer Gene Database. Click here. For an explanation of fields in this database and here. For an explanation of study interpretation for this database.

ccgd-starrlab.oit.umn.edu ccgd-starrlab.oit.umn.edu

Tutorial for the Candidate Cancer Gene Database (CCGD)

http://ccgd-starrlab.oit.umn.edu/tutorial.php

Candidate Cancer Gene Database. 1 Determine if a Gene of Interest is a Cancer Driver Gene. 2 Determine Cancer Driver Genes in a Cancer of Interest. 3 Determine Cancer Driver Genes in a Study of Interest. 1 Determine if a Gene of Interest is a Cancer Driver Gene. Click on the Search menu option to reach the Search page. Select “All cancers” or any specific cancers in the Cancer field. You can use Control-click (PC) or Command-click (Mac) to select multiple menu options. Select “ID” or “s...The CCGD will r...

ccgd-starrlab.oit.umn.edu ccgd-starrlab.oit.umn.edu

Help for the Candidate Cancer Gene Database (CCGD)

http://ccgd-starrlab.oit.umn.edu/help.php

Candidate Cancer Gene Database. See the help headings below. See the help headings below. How do I use the database? To view a brief tutorial. Do you have a bibliography of studies used in this database? To view a list of sources in PubMed. What do the fields in this database mean? How was the relative rank determined for a specific study? For a general explanation of the relative rank process. Click here. For an explanation of relative ranking for each study. See the NCBI Genome site.

previous.malacards.org previous.malacards.org

MalaCards - human disease database

http://previous.malacards.org/pages/info/id:sources

What's in a MalaCard. MalaCards is an integrated searchable database of human maladies and their annotations, modeled on the architecture and richness of the popular GeneCards. Database of human genes. And their associated genes. Each "card" contains a variety of detailed sections. For example, see our Sample Malady. What's in a MalaCard? This page provides information about the various MalaCards sections and tables. Unifying names and acronyms, and organizing characterizations. Between the disease name ...

previous.malacards.org previous.malacards.org

MalaCards - human disease database

http://previous.malacards.org/pages/info

What's in a MalaCard. MalaCards is an integrated searchable database of human maladies and their annotations, modeled on the architecture and richness of the popular GeneCards. Database of human genes. And their associated genes. Each "card" contains a variety of detailed sections. For example, see our Sample Malady. What's in a MalaCard? This page provides information about the various MalaCards sections and tables. Unifying names and acronyms, and organizing characterizations. Between the disease name ...

grch37-cancer.sanger.ac.uk grch37-cancer.sanger.ac.uk

COSMIC: COSMIC Datasheets

http://grch37-cancer.sanger.ac.uk/cosmic/datasheets

Full description of new v78 content. New fully curated cancer genes;. HIF1A - 1,782 samples, 196 mutations, 56 papers. MTOR - 3,239 samples, 634 mutations, 132 papers. PTPN13 - 1,761 samples, 429 mutations, 85 papers. Curated Gene Fusions;. ETV6-RUNX1 - 2,276 samples, 357 mutations, 37 papers. Cancer Gene Census;. 9 new genes added, 1 removed. Drug Resistance; 1 new gene (FLT3) and 2 new drugs (Quizartinib and Sorafenib), 76 new unique resistance mutations curated. ICGC release 21; May 16. Hypoxia induci...

genegrid.genomatix.com genegrid.genomatix.com

User Manual | Documentation | GeneGrid

https://genegrid.genomatix.com/grid/doc/help/user-manual

GeneGrid enables you to quickly interpret SNVs and small indel variants from human sequencing data. Variants from targeted panels, exome and whole genome sequencing are annotated using a variety of annotation sources. You can filter the list for those annotated variants in the samples individually, perform trio analyses or compare case and control sets using multiple samples. GeneGrid is designed to support the latest web browsers. We support the current versions of Chrome. And Internet Explorer 11.

grch37-cancer.sanger.ac.uk grch37-cancer.sanger.ac.uk

COSMIC: Data Submission Page

http://grch37-cancer.sanger.ac.uk/cosmic/submissions

I am an author, how should I describe mutation data in my publications? We list here some guidelines for authors to help improve the speed of curation for an increasing volume of literature relevant to COSMIC and to ensure the continuing accuracy of our curation. By following these guidelines authors will contribute to the quick and efficient dissemination of their research results via COSMIC. It is much easier and quicker for us to map reported mutations to COSMIC reference sequences if the author has s...

grch37-cancer.sanger.ac.uk grch37-cancer.sanger.ac.uk

COSMIC: Help home page

http://grch37-cancer.sanger.ac.uk/cosmic/help

Welcome to the COSMIC Help Pages. Please select a help topic from the index on the right hand panel. The Catalogue Of Somatic Mutations In Cancer (COSMIC) is a comprehensive database of somatic mutations. This dataset can be examined in the following ways -. COSMIC Website: grch37-cancer.sanger.ac.uk/cosmic. COSMIC Whole Genomes: grch37-cancer.sanger.ac.uk/wgs. COSMIC Cell Lines Project: grch37-cancer.sanger.ac.uk/cell lines. COSMIC Genome Browser: grch37-cancer.sanger.ac.uk/jbrowse/? After searching, th...

grch37-cancer.sanger.ac.uk grch37-cancer.sanger.ac.uk

COSMIC: Cancer Browser

http://grch37-cancer.sanger.ac.uk/cosmic/browse/tissue

Adrenal gland ( 2146 / 8624 ). Autonomic ganglia ( 786 / 7626 ). Biliary tract ( 1630 / 6466 ). Bone ( 1582 / 8888 ). Breast ( 9532 / 46239 ). Central nervous system ( 15975 / 53111 ). Cervix ( 546 / 5733 ). Endometrium ( 3348 / 16164 ). Eye ( 1128 / 3828 ). Fallopian tube ( 3 / 10 ). Gastrointestinal tract (site indeterminate) ( 139 / 1512 ). Genital tract ( 206 / 681 ). Haematopoietic and lymphoid tissue ( 101853 / 400204 ). Kidney ( 4163 / 15193 ). Large intestine ( 44005 / 178395 ). NS ( 1814 / 4977 ).

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Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

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