grch37-cancer.sanger.ac.uk

COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page

Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

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COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page | grch37-cancer.sanger.ac.uk Reviews

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Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

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COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page | grch37-cancer.sanger.ac.uk Reviews

https://grch37-cancer.sanger.ac.uk

Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

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grch37-cancer.sanger.ac.uk

1

COSMIC: Cancer Browser

http://grch37-cancer.sanger.ac.uk/cosmic/browse/tissue

Adrenal gland ( 2146 / 8624 ). Autonomic ganglia ( 786 / 7626 ). Biliary tract ( 1630 / 6466 ). Bone ( 1582 / 8888 ). Breast ( 9532 / 46239 ). Central nervous system ( 15975 / 53111 ). Cervix ( 546 / 5733 ). Endometrium ( 3348 / 16164 ). Eye ( 1128 / 3828 ). Fallopian tube ( 3 / 10 ). Gastrointestinal tract (site indeterminate) ( 139 / 1512 ). Genital tract ( 206 / 681 ). Haematopoietic and lymphoid tissue ( 101853 / 400204 ). Kidney ( 4163 / 15193 ). Large intestine ( 44005 / 178395 ). NS ( 1814 / 4977 ).

2

CELL_LINES: Cell lines Project - Home Page

http://grch37-cancer.sanger.ac.uk/cell_lines

Cell lines v78, released 05-SEP-16. COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Start using COSMIC by searching for a gene, cancer type, mutation, etc. below, or by browsing a region of the human genome using the map to the right. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. If you would b...

3

COSMIC: Data Submission Page

http://grch37-cancer.sanger.ac.uk/cosmic/submissions

I am an author, how should I describe mutation data in my publications? We list here some guidelines for authors to help improve the speed of curation for an increasing volume of literature relevant to COSMIC and to ensure the continuing accuracy of our curation. By following these guidelines authors will contribute to the quick and efficient dissemination of their research results via COSMIC. It is much easier and quicker for us to map reported mutations to COSMIC reference sequences if the author has s...

4

COSMIC: Help home page

http://grch37-cancer.sanger.ac.uk/cosmic/help

Welcome to the COSMIC Help Pages. Please select a help topic from the index on the right hand panel. The Catalogue Of Somatic Mutations In Cancer (COSMIC) is a comprehensive database of somatic mutations. This dataset can be examined in the following ways -. COSMIC Website: grch37-cancer.sanger.ac.uk/cosmic. COSMIC Whole Genomes: grch37-cancer.sanger.ac.uk/wgs. COSMIC Cell Lines Project: grch37-cancer.sanger.ac.uk/cell lines. COSMIC Genome Browser: grch37-cancer.sanger.ac.uk/jbrowse/? After searching, th...

5

COSMIC: Catalogue Of Somatic Mutations In Cancer

http://grch37-cancer.sanger.ac.uk/cosmic/papers

COSMIC Genome-Wide Screen Curation. This is a complete list of large scale systematic screen papers and genome wide screen papers curated in COSMIC. Whole Genome and Large-scale Systematic screens. This tab shows an exportable and searchable table of whole genome shotgun sequencing screens [more details]. This tab shows an exportable and searchable table of ICGC/TCGA screens [more details].

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cancer.sanger.ac.uk

COSMIC: Help - Frequently Asked Questions

http://cancer.sanger.ac.uk/cosmic/help/faq

Frequently Asked Questions ( FAQ ). Can I download the full COSMIC dataset? The export sheets are updated with each COSMIC release, the file can be found here : CosmicMutantExport.tsv.gz. This file contains all the samples analysed for every gene in COSMIC found with mutations. For targeted gene screens there is also a file ( CosmicCompleteTargetedScreensMutantExport.tsv.gz. Where can I download all the mutations from COSMIC? How can I find the latest COSMIC release version? Each sample has its own name ...

cancer.sanger.ac.uk

COSMIC: Help home page

http://cancer.sanger.ac.uk/cosmic/help

Welcome to the COSMIC Help Pages. Please select a help topic from the index on the right hand panel. The Catalogue Of Somatic Mutations In Cancer (COSMIC) is a comprehensive database of somatic mutations. This dataset can be examined in the following ways -. COSMIC Website: cancer.sanger.ac.uk/cosmic. COSMIC Whole Genomes: cancer.sanger.ac.uk/wgs. COSMIC Cell Lines Project: cancer.sanger.ac.uk/cell lines. COSMIC Genome Browser: cancer.sanger.ac.uk/jbrowse/? For database dump files. After searching, the r...

cancer.sanger.ac.uk

COSMIC: COSMIC Data Analyses

http://cancer.sanger.ac.uk/cosmic/analyses

Exclusion of hypermutated samples and SNP filtering:. Cancer genomes can be a very noisy source of data. It is estimated that an individual's tumour is caused by 5-10 driver mutations, but genome resequencing regularly reveals over 10,000 somatic mutations per tumour, with much larger numbers not unusual in hypermutated samples (we've seen samples with over 100,000 mutations each, the greatest being 178,763). More information about FATHMM-MKL is available here. The new method improves on the older versio...

cancer.sanger.ac.uk

COSMIC: Data Submission Page

http://cancer.sanger.ac.uk/cosmic/submissions

I am an author, how should I describe mutation data in my publications? We list here some guidelines for authors to help improve the speed of curation for an increasing volume of literature relevant to COSMIC and to ensure the continuing accuracy of our curation. By following these guidelines authors will contribute to the quick and efficient dissemination of their research results via COSMIC. It is much easier and quicker for us to map reported mutations to COSMIC reference sequences if the author has s...

cancer.sanger.ac.uk

COSMIC: Login Page

https://cancer.sanger.ac.uk/biomart/martview

Please note we use cookies to identify your user name, and by logging in you accept that we will write a cookie to your computer. In order to download COSMIC data, you will need to register by clicking on the following link. Wellcome Trust Sanger Institute, Genome Research Limited (reg no. 2742969) is a charity registered in England with number 1021457.

cancer.sanger.ac.uk

COSMIC: Expert curation - what we do

http://cancer.sanger.ac.uk/cosmic/curation

Expert Curation of Genes. Expert manual curation allows the capture of very high detail across mutation positions, disease descriptions, and other patient and population data. Manual curation additionally provides improved quality control over systematic approaches. Experienced curators can identify inconsistencies or errors in publications, allowing the rejection of untrustworthy, incomplete or unspecific data sources. Key points about expert curated data. Selecting papers from the literature. Tumour so...

cancer.sanger.ac.uk

COSMIC: Cancer Gene census

http://cancer.sanger.ac.uk/census

The cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer. And supplemental analysis information. Related to the paper is also available. This tab shows census genes broken down by mutation/aberration class. [more details]. This tab shows a table of abbreviations used in the census tables. [more details].

cancer.sanger.ac.uk

COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page

http://cancer.sanger.ac.uk/cancergenome/projects/cosmic

High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. Genomic Landscape of Cancer. All COSMIC services (including website and downloads) will be unavailable from the 26th to 30th August 2016. We do apologise for the disruption to our service and any inconvenience this causes, and recommend that all downloads are completed by 17:00 BST (current UK time) on 26th August. COSMIC now curates drug resistance mutations. In v77; AR.

cancer.sanger.ac.uk

COSMIC: Licensing Strategy for COSMIC

http://cancer.sanger.ac.uk/cosmic/license

Paving the way for COSMIC’s future. New licensing strategy with commercial partners will spur cancer database’s growth. Cancer researchers around the world are producing valuable genetic data at an unprecedented scale thanks to advances in sequencing technology. COSMIC data supports and underlies research and development in cancer drug discovery and diagnostics by compiling these genetic data from peer-reviewed research and international databases into a single curated system. Please check our FAQ. Wellc...

cancer.sanger.ac.uk

COSMIC: Cosmic Genome Browser

http://cancer.sanger.ac.uk/cosmic/browse/genome

All COSMIC curated data including whole genomes. All exome sequencing/array data from the Cell Lines Project. Samples which have undergone whole genome or exome sequencing. Welcome to the COSMIC Genome Browser. This site contains all the cancer genetic data curated into COSMIC, providing a genomic visualisation. Additional genomic annotations are provided to give a much broader perspective on the impact of these somatic mutations. The COSMIC Genome Browser. Is a JBrowse instance.

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COSMIC: Catalogue of Somatic Mutations in Cancer - Home Page

Data Download ▼. High quality curation by expert postdoctoral scientists. Additional tools to explore COSMIC. Further details on using COSMIC's content. How do we annotate genomes? Genomic Landscape of Cancer. Coding mutation consequence (most severe), as predicted by the VEP. The COSMIC Genome Browser. Displays all mutation information across all cancers and has been enhanced in v73 to include ENCODE regulatory features and all available SNPs. For more details, please see the datasheet. Wellcome Trust S...

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